Breastfeeding patterns and total volume of human milk consumed influence the development of the infant oral microbiome.

IF 3.7 2区 医学 Q2 MICROBIOLOGY
Journal of Oral Microbiology Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI:10.1080/20002297.2025.2469892
Roaa A Arishi, Zoya Gridneva, Sharon L Perrella, Ali S Cheema, Ching T Lai, Matthew S Payne, Donna T Geddes, Lisa F Stinson
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引用次数: 0

Abstract

Background: The oral microbiome of breastfed infants is distinct from that of formula-fed infants. However, breastfeeding characteristics, such as time spent breastfeeding (min/24 h), breastfeeding frequency (number of breastfeeds per day), and human milk intake (ml/day) vary significantly between breastfeeding dyads.

Objectives: Given that human milk and breastfeeding exposures likely influence early colonisation of the infant oral microbiome, this study aimed to elucidate the impact of breastfeeding characteristics on the development of the infant oral microbiome.

Materials and methods: Oral swabs (n = 55) were collected from infants at three months of age, alongside breastfeeding data collected over a 24-hour period. Bacterial DNA profiles were analysed using full-length 16S rRNA gene sequencing.

Results: Variations in breastfeeding characteristics contributed to differences in microbial community structure. Total breastfeeding duration (min/24 h) was positively associated with Bifidobacterium longum and Lactobacillus gasseri, while breastfeeding frequency was negatively associated with Veillonella sp. Additionally, human milk intake (ml/24 h) was negatively associated with Streptococcus parasanguinis.

Conclusion: These findings underscore the significant influence of early life feeding practices on oral microbial communities and emphasise the importance role of breastfeeding in shaping the oral microbiome during early life.

母乳喂养方式和人乳总量影响婴儿口腔微生物群的发育。
背景:母乳喂养婴儿的口腔微生物群不同于配方奶粉喂养婴儿。然而,母乳喂养特征,如母乳喂养时间(分钟/24小时)、母乳喂养频率(每天母乳喂养次数)和母乳摄入量(毫升/天)在母乳喂养的两对之间差异很大。目的:考虑到母乳和母乳喂养可能会影响婴儿口腔微生物群的早期定植,本研究旨在阐明母乳喂养特征对婴儿口腔微生物群发育的影响。材料和方法:从3个月大的婴儿中收集口腔拭子(n = 55),同时收集24小时内的母乳喂养数据。采用16S rRNA全长测序法分析细菌DNA谱。结果:母乳喂养特征的不同导致了微生物群落结构的差异。总母乳喂养时间(min/24 h)与长双歧杆菌和干酪乳杆菌呈正相关,而母乳喂养频率与细络杆菌呈负相关。此外,人乳摄入量(ml/24 h)与副血链球菌呈负相关。结论:这些发现强调了生命早期喂养习惯对口腔微生物群落的重要影响,并强调了母乳喂养在塑造生命早期口腔微生物群中的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.00
自引率
4.40%
发文量
52
审稿时长
12 weeks
期刊介绍: As the first Open Access journal in its field, the Journal of Oral Microbiology aims to be an influential source of knowledge on the aetiological agents behind oral infectious diseases. The journal is an international forum for original research on all aspects of ''oral health''. Articles which seek to understand ''oral health'' through exploration of the pathogenesis, virulence, host-parasite interactions, and immunology of oral infections are of particular interest. However, the journal also welcomes work that addresses the global agenda of oral infectious diseases and articles that present new strategies for treatment and prevention or improvements to existing strategies. Topics: ''oral health'', microbiome, genomics, host-pathogen interactions, oral infections, aetiologic agents, pathogenesis, molecular microbiology systemic diseases, ecology/environmental microbiology, treatment, diagnostics, epidemiology, basic oral microbiology, and taxonomy/systematics. Article types: original articles, notes, review articles, mini-reviews and commentaries
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