{"title":"Self-nanoemulsifying drug delivery system (SNEDDS) as nano-carrier framework for permeability modulating approaches of BCS class III drug.","authors":"Amulya Jindal, Pankaj Kumar Sharma, Anoop Kumar","doi":"10.1080/1061186X.2025.2469751","DOIUrl":null,"url":null,"abstract":"<p><p>The purpose of this review is to focus on the Self-Nanoemulsifying Drug Delivery System (SNEDDS) as an effective nanocarrier framework for permeability modulating approaches (PMA) of BCS class-III drugs and its challenges. Present review updates the recent trends in the SNEDDS research where it was employed as a cargo carrier for PMA and challenges. Patient compliance, ease of administration and non-invasiveness mode are non-trivial aspects in the oral administration of drugs. However, low aqueous solubility and impaired permeability are two prominent challenges resulting poor absorption of a drug. SNEDDS emerged as a dual nano-carrier system to enable nanodispersion of PMA via e.g. ion-pairing, phospholipid-complex, surfactant-drug interaction, loading of non-ionizable, free drug bases etc. These PMAs are embedded within the lipid phase of SNEDDS to produce nanosizing, enhancing nano-dispersibility via micellization/solubilization mechanism owing to its ternary components. Review highlights different PMAs employed in bioavailability enhancement of BCS class-III. It covers excipients employed in SNEDDS-loaded PMA, strategies for the hydrophobic transformation of water-soluble drugs for BCS class-III drugs. SNEDDS as a nano-cargo system for PMAs significantly modifies the bioavailability of BCS class-III drugs. SNEDDS is an isotropic-mixture of oil, surfactant:co-surfactant offers multipoint access to PMA loading and produces nano-dispersion in aqueous-medium.</p>","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-21"},"PeriodicalIF":4.3000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug Targeting","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1061186X.2025.2469751","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
The purpose of this review is to focus on the Self-Nanoemulsifying Drug Delivery System (SNEDDS) as an effective nanocarrier framework for permeability modulating approaches (PMA) of BCS class-III drugs and its challenges. Present review updates the recent trends in the SNEDDS research where it was employed as a cargo carrier for PMA and challenges. Patient compliance, ease of administration and non-invasiveness mode are non-trivial aspects in the oral administration of drugs. However, low aqueous solubility and impaired permeability are two prominent challenges resulting poor absorption of a drug. SNEDDS emerged as a dual nano-carrier system to enable nanodispersion of PMA via e.g. ion-pairing, phospholipid-complex, surfactant-drug interaction, loading of non-ionizable, free drug bases etc. These PMAs are embedded within the lipid phase of SNEDDS to produce nanosizing, enhancing nano-dispersibility via micellization/solubilization mechanism owing to its ternary components. Review highlights different PMAs employed in bioavailability enhancement of BCS class-III. It covers excipients employed in SNEDDS-loaded PMA, strategies for the hydrophobic transformation of water-soluble drugs for BCS class-III drugs. SNEDDS as a nano-cargo system for PMAs significantly modifies the bioavailability of BCS class-III drugs. SNEDDS is an isotropic-mixture of oil, surfactant:co-surfactant offers multipoint access to PMA loading and produces nano-dispersion in aqueous-medium.
期刊介绍:
Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs.
Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.