The Effects of Prebiotic Supplementation on Markers of Exercise-Induced Gastrointestinal Syndrome in Response to Exertional Heat Stress.

IF 3 3区 医学 Q2 NUTRITION & DIETETICS
Christopher E Rauch, Kayla Henningsen, Isabel Martinez, Pascale Young, Alice Mika, Zoya Huschtscha, Alan McCubbin, Rebecca Henry, Doville Anderson, Ricardo J S Costa
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引用次数: 0

Abstract

Exercise perturbs various aspects of gastrointestinal integrity and function, which may lead to performance impeding gastrointestinal symptoms (GIS) and/or precipitate clinical issues warranting medical management. This study aimed to determine the impact of prebiotic supplementation on gastrointestinal integrity and functional status in response to exertional heat stress (EHS). Sixteen endurance athletes completed two trials of 3-hr running at 60% V˙O2max in 30 °C at baseline (T1) and following an 8-week supplementation period (T2), with 16 g/day prebiotic (PREBIOTIC) or matched placebo (PLACEBO). Blood samples were collected pre-EHS and post-EHS and in recovery for determination of stress response (cortisol), intestinal epithelial injury (intestinal fatty acid binding protein), bacterial endotoxemia (sCD14), and systemic inflammation (C-reactive protein). GIS and feeding tolerance variables were assessed throughout the EHS. Orocecal transit time was determined via a lactulose challenge given at 2.5 hr into EHS. Plasma cortisol (combined mean: +252 ng/ml), intestinal fatty acid binding protein (+800 pg/ml), and sCD14 (+487 ng/ml) concentrations increased in response to EHS in T1 (p ≤ .05), but not for C-reactive protein (+0.8 μg/ml; p > .05), in both PREBIOTIC and PLACEBO. PREBIOTIC supplementation resulted in a blunted intestinal fatty acid binding protein response on T2 (+316 pg/ml) compared with an increase (+1,001 ng/ml) in PLACEBO (p = .005). Lower sCD14 was observed at T2 (2,799 ng/ml) versus T1 (3,246 ng/ml) in PREBIOTIC only (p = .039). No intervention effects were observed for C-reactive protein. No difference within or between PREBIOTIC and PLACEBO at T1 and T2 was observed for orocecal transit time, GIS, and feeding tolerance. In conclusion, 8 weeks of prebiotic supplementation modestly attenuates EHS associated perturbations to intestinal integrity, but does not further impair gastrointestinal transit and/or exacerbate EHS associated GIS or feeding tolerance.

补充益生元对运动性热应激下运动性胃肠综合征标志物的影响。
运动干扰胃肠道完整性和功能的各个方面,这可能导致性能障碍胃肠道症状(GIS)和/或沉淀的临床问题,需要医疗管理。本研究旨在确定补充益生元对运动性热应激(EHS)下胃肠道完整性和功能状态的影响。16名耐力运动员完成了两项试验,分别是在基线(T1)和8周补充期(T2)下,以60% V˙O2max在30°C下跑步3小时,每天服用16克益生元(prebiotic)或匹配的安慰剂(placebo)。采集ehs前、ehs后和恢复期的血样,测定应激反应(皮质醇)、肠上皮损伤(肠脂肪酸结合蛋白)、细菌内毒素血症(sCD14)和全身性炎症(c反应蛋白)。在整个EHS过程中评估GIS和喂养公差变量。在进入EHS的2.5小时内,通过乳果糖激发来确定ococecal传递时间。血浆皮质醇(综合平均值:+252 ng/ml)、肠道脂肪酸结合蛋白(+800 pg/ml)和sCD14 (+487 ng/ml)浓度在T1时随EHS升高(p≤0.05),但c -反应蛋白(+0.8 μg/ml)没有升高(p≤0.05);p < 0.05)。益生元补充剂导致肠道脂肪酸结合蛋白对T2的反应减弱(+316 pg/ml),而安慰剂组增加(+1,001 ng/ml) (p = 0.005)。仅在益生元组中,T2 (2,799 ng/ml)与T1 (3,246 ng/ml)相比,sCD14较低(p = 0.039)。未观察到干预对c反应蛋白的影响。在T1和T2时,益生元组和安慰剂组在口腔运输时间、GIS和喂养耐受方面没有差异。综上所述,8周的益生元补充可适度减轻EHS对肠道完整性的影响,但不会进一步损害胃肠道运输和/或加剧EHS相关的GIS或摄食耐受性。
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来源期刊
CiteScore
5.00
自引率
8.00%
发文量
50
审稿时长
6-12 weeks
期刊介绍: The International Journal of Sport Nutrition and Exercise Metabolism (IJSNEM) publishes original scientific investigations and scholarly reviews offering new insights into sport nutrition and exercise metabolism, as well as articles focusing on the application of the principles of biochemistry, physiology, and nutrition to sport and exercise. The journal also offers editorials, digests of related articles from other fields, research notes, and reviews of books, videos, and other media releases. To subscribe to either the print or e-version of IJSNEM, press the Subscribe or Renew button at the top of your screen.
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