Body Mass Index (BMI) as a Prognostic Factor Influencing Outcomes of Gastric Cancer Resection Including Curative Gastrectomy.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-03-01 DOI:10.21873/invivo.13917

Oliwia Majewska, Radosław Pach, Paweł Brzewski, Jan Kulig, Piotr Kulig

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引用次数: 0

Abstract

Background/aim: This study evaluated the influence of the body mass index (BMI) on outcomes of gastric cancer resection, with a specific focus on curative gastrectomy.

Patients and methods: A total of 756 patients who underwent gastric cancer resection, including 372 cases of curative gastrectomy, were analyzed. The impact of BMI on overall, systemic, and surgical complications, as well as on relaparotomy, perioperative mortality, and 5-year survival was examined.

Results: Underweight (BMI <18.5 kg/m²), and obesity (BMI ≥30 kg/m²) were identified as independent risk factors for overall complications (p<0.0001, and p<0.0001), systemic complications (p<0.0001, and p=0.001), and surgical complications (p<0.0001, and p=0.023) in all gastric cancer resections. Similar trends were observed for curative gastrectomy, where underweight and obese patients demonstrated more overall complications (p<0.0001, and p<0.0001), systemic complications (p<0.001, and p=0.0001), and surgical complications (p<0.0001, and p=0.0032). No differences in 5-year survival were observed among BMI categories in 372 cases of curative gastrectomy. However, being underweight was associated with a poorer 5-year survival in all 756 cases of gastric cancer resection (odds ratio=0.45, 95% confidence interval= 0.27-0.73, p=0.0016).

Conclusion: BMI significantly influences the outcomes of gastric cancer resection, with underweight and obese patients demonstrating higher complication rates. Underweight status is also linked to poorer long-term survival in the broader gastric cancer population but not in curative resection cases.

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.