New-onset Bipolar Disorder in Hidradenitis Suppurativa Patients: A Multi-center, Propensity-score-matched Cohort Study.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-03-01 DOI:10.21873/invivo.13911

Meng-Che Wu, Yun-Feng Li, Chen-Yu Lin, Nung-Hsiang Lin, Chien-Ying Lee, Yu-Jung Su, Hui-Chin Chang, Shuo-Yan Gau

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引用次数: 0

Abstract

Background/aim: Hidradenitis suppurativa (HS) may be linked to an elevated risk of bipolar disorder, though the precise mechanism remains unclear. This study investigated the likelihood of bipolar disorder in patients with HS.

Patients and methods: We analyzed the electronic health records of 60,850 patients with HS and 60,850 matched controls from the TriNetX network, excluding those with a prior bipolar disorder diagnosis. Propensity score matching was conducted (1:1 ratio), and hazard ratios (HRs) were calculated to assess the risk of new-onset bipolar disorder in patients with HS compared to controls.

Results: After matching, the HR for developing bipolar disorder in patients with HS was 1.549 [95% confidence interval (CI)=1.270-1.889] after a 1-year follow-up, remaining significant in 3- and 5-year follow-ups and sensitivity analyses. Stratified by sex, female patients with HS showed a notably higher risk (HR=1.509, 95%CI=1.353-1.683), while no significant increase was seen in males.

Conclusion: Patients with HS have a significantly elevated risk of developing bipolar disorder, especially among females. Healthcare providers should be mindful of this association when treating patients with HS.

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背景/目的：化脓性扁平湿疹（HS）可能与躁狂症风险升高有关，但其确切机制仍不清楚。本研究调查了HS患者罹患躁郁症的可能性：我们分析了来自 TriNetX 网络的 60,850 名 HS 患者和 60,850 名匹配对照者的电子健康记录，其中排除了既往有躁郁症诊断的患者。我们进行了倾向得分匹配（1:1 比例），并计算了危险比（HRs），以评估与对照组相比，HS 患者新发双相情感障碍的风险：结果：经过匹配后，HS患者在随访1年后出现躁郁症的危险比为1.549[95%置信区间（CI）=1.270-1.889]，在随访3年、5年和敏感性分析中仍然显著。按性别分层，女性 HS 患者的风险明显更高（HR=1.509，95%CI=1.353-1.683），而男性患者的风险没有显著增加：结论：HS 患者罹患躁郁症的风险明显升高，尤其是女性患者。结论：HS 患者罹患双相情感障碍的风险明显升高，尤其是女性患者。医护人员在治疗 HS 患者时应注意这种关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.