A New Approach to Highly Conformal Hippocampal-sparing Whole-brain Radiotherapy: A Feasibility Study.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-03-01 DOI:10.21873/invivo.13886

Christian Ziemann, Florian Cremers, Miller MacPherson, Dirk Rades, Anastassia Löser

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引用次数: 0

Abstract

Background/aim: Hippocampal-sparing whole-brain radiotherapy (HS-WBRT) is increasingly used for multiple brain metastases. However, most studies have not reported dose conformity indices (CI). In the only study indicating the CI, conformity was low (CI=0.7). We developed a new technique to achieve a significantly higher CI and better dose coverage.

Patients and methods: Ten patients received 30 Gy of HS-WBRT for brain metastases. Three variants of treatment plans (VAR1, VAR2, VAR3) were investigated. Volumetric modulated arc therapy plans with two (2ROT) or three rotations (3ROT) were created for each variant. Plans were compared for compliance with hippocampal sparing criteria, CI (where a higher value indicates better conformity), and homogeneity index (HI, where a lower value indicates better homogeneity).

Results: Best results (highest CI, lowest HI) were achieved with the VAR3-3ROT technique (a new method), which yielded a CI=0.92-0.95 and a HI=0.05-0.09. VAR3-2ROT led to a CI=0.90-0.95 and a HI=0.06-0.11. With the other techniques, CI and HI ranged between 0.77-0.87 and 0.15-0.32, respectively.

Conclusion: Our new technique achieved both appropriate hippocampal sparing and very high dose conformity of ≥0.9. Significant underdosage outside the hippocampal-sparing area was avoided.

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.