{"title":"Successful rivaroxaban and doxycycline therapy for <i>Mycoplasma pneumonia</i> with pulmonary embolism in children: a case report.","authors":"Fang Xiaoqian, Lu Hemin","doi":"10.3389/fped.2025.1449493","DOIUrl":null,"url":null,"abstract":"<p><p>The mortality of pulmonary embolism in children is high, and there is no standardized treatment protocol. We present a case of successful treatment of <i>Mycoplasma pneumoniae</i> (<i>M pneumoniae</i>) with pulmonary embolism in a child using rivaroxaban and doxycycline, thereby exploring a more appropriate treatment option. A 10-year-old male presented with fever, cough, and chest pain as the main symptoms. <i>M pneumoniae</i> polymerase chain reaction of bronchoalveolar lavage fluid was positive, and computed tomography angiography indicated pulmonary embolism. Azithromycin, doxycycline, and piperacillin-tazobactam were administered sequentially for infection control, while methylprednisolone was given to control inflammation and heparin and rivaroxaban for sequential treatment, resulting in a satisfactory recovery.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1449493"},"PeriodicalIF":2.1000,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861191/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fped.2025.1449493","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
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Abstract
The mortality of pulmonary embolism in children is high, and there is no standardized treatment protocol. We present a case of successful treatment of Mycoplasma pneumoniae (M pneumoniae) with pulmonary embolism in a child using rivaroxaban and doxycycline, thereby exploring a more appropriate treatment option. A 10-year-old male presented with fever, cough, and chest pain as the main symptoms. M pneumoniae polymerase chain reaction of bronchoalveolar lavage fluid was positive, and computed tomography angiography indicated pulmonary embolism. Azithromycin, doxycycline, and piperacillin-tazobactam were administered sequentially for infection control, while methylprednisolone was given to control inflammation and heparin and rivaroxaban for sequential treatment, resulting in a satisfactory recovery.
期刊介绍：
Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.
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