Asymmetric Amination of 1,2-Diol through Borrowing Hydrogen: Synthesis of Vicinal Amino α-Tertiary Alcohol.

Abstract

Methods to prepare vicinal amino alcohols are important because of their presence in biologically active compounds. Despite the development of various methods for vicinal amino alcohol synthesis, C(sp3)-rich oxygen-containing β-amine compounds continue to pose great challenge. While ring-opening reaction of epoxides with amine nucleophile is the prime method for vicinal amino alcohol preparation, epoxides are highly reactive and sometimes difficult to make, resulting in drawbacks regarding selectivity of this approach. Here, we report a catalytic enantio-convergent amination of α-tertiary 1,2-diols for the efficient access to vicinal amino α-tertiary alcohols. The racemic α-tertiary 1,2-diol substrates of different alkyl/aryl or alkyl/alkyl backbone, can be converted to chiral vicinal amino a-tertiary alcohols through diphenyl phosphate-mediated RuCl3 catalysed asymmetric borrowing hydrogen (ABH) pathway. This simple ABH reaction can be scaled up to the synthesis of chiral ligands, synthetic intermediates, and other medicinally-relevant compounds. Overall, this catalytic redox-neutral procedure broadens the scope of Ru-catalysed amination of alcohols and discloses an underexplored step- and atom-economical synthetic strategy for the synthesis of vicinal amino α-tertiary alcohols and provides a practicable alternative to the present benchmark procedures.