Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention.

IF 8.1 1区医学 Q1 CLINICAL NEUROLOGY

Annals of Neurology Pub Date : 2025-02-27 DOI:10.1002/ana.27210

Alison M H Donald, Luiz G N de Almeida, Mohamed Ziad Dabaja, Isabella Orchard, Kaia Ybema, Veronica Tsegai, Victoria Armstrong, Sophie Smith, Daniel Young, Richard Stewart Longman, Amanda V Tyndall, Jean M Rawling, Michael D Hill, Willis H Tsai, Ejaife Agbani, Marc J Poulin, Antoine Dufour

引用次数: 0

Abstract

The physiological basis of cognitive decline remains largely uncharacterized. We identified a protein panel signature, in living humans, that correlates to improvement in neurocognition over a period of 5 years. Our signature is composed of complement proteins, coagulation cascade, and extracellular matrix regulators. In our cohort, SERPINF1 is associated with greater maximal oxygen uptake after an aerobic exercise intervention. Sleep quality is also a key factor in relation to inter-alpha-trypsin inhibitor heavy chain H2, which was associated with greater sleep efficiency. Additionally, we validate that the coagulation profile of decliners' plasma contains procoagulant agonists, leading to greater platelet activation. ANN NEUROL 2025.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.