Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-04-01 DOI:10.1016/j.tibs.2025.02.001

Christian Blum , Mireille M.A.E. Claessens

引用次数: 0

Abstract

A recent report by Makasewicz et al. delineates how α-synuclein (αSyn) membrane-binding modes drive amyloid formation. Their in vitro data reveal a lipid-to-protein (L/P) ratio tipping point influencing fibril formation. Preliminary validation from existing literature supports that these findings are also relevant in cellular contexts, informing potential new disease-modulating strategies.

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平衡作用：脂质与蛋白质的比例控制α-突触核蛋白的聚集命运。

Makasewicz等人最近的一份报告描述了α-突触核蛋白（αSyn）膜结合模式如何驱动淀粉样蛋白的形成。他们的体外数据揭示了影响纤维形成的脂质与蛋白质（L/P）比率临界点。现有文献的初步验证支持这些发现也与细胞背景相关，为潜在的新疾病调节策略提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.