Instant nanocapsule formulation based on self-assembly of alginate with quaternary ammonium to improve the encapsulation efficiency, photostability, and insecticidal activity of emamectin benzoate

IF 2.1 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2025-02-28 DOI:10.1007/s11051-025-06266-6

Xiaoqiu Wen, Fengjun Cai, Qiao Yang, Yunfang Zhang, Shengqian Wu, Min Zhang, Lin Ma

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引用次数: 0

Abstract

Nanocapsule was obtained by self-assembling of sodium alginate (SA) with cetyl trimethyl ammonium bromide (CTAB) and Tween 80 in a coarse dispersion of butyl acetate and turned out to be a good carrier of emamectin benzoate (EB). The nanocapsule exhibited better storing stability, anti-photolysis property, foliar wettability, and retention, as compared to the conventional concentrated emulsion of EB (EB-EC). Incorporation into the nanocapsule retarded the release of EB, which was pH-sensitive and dependent on the structure of the nanocapsule. A better sustaining effect could be achieved by an increase of SA or a reduction of CTAB and in a basic environment, due to the enhanced interaction between the active ingredient and the shell matrix of the nanocapsule. The incorporation into the nanocapsule greatly increased the activity of EB. The median lethal concentration of typical positively charged nanocapsule EB@SA_0.1CTAB_0.4Tw_0.2 against Mythimna separata larvae was 48% of that of commercial EB-EC, after feeding to the insect for 48 h. The result indicated that the self-assembling of SA and CTAB was a good strategy to fabricate instant nanoformulation under mild conditions and with high efficiency and low cost, which was valuable to prompt nanopesticides from laboratory investigation to field application.

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以海藻酸盐与季铵自组装为基础，制备快速纳米胶囊，提高其包封效率、光稳定性和杀虫活性

将海藻酸钠（SA）与十六烷基三甲基溴化铵（CTAB）和Tween 80在乙酸丁酯的粗分散体中自组装得到纳米胶囊，并证明其是苯甲酸埃维菌素（EB）的良好载体。与常规EB （EB- ec）浓缩乳液相比，该纳米胶囊具有更好的储存稳定性、抗光解性、叶面润湿性和保持性。纳米胶囊的掺入延缓了EB的释放，EB的释放与纳米胶囊的结构有关，且对ph敏感。在碱性环境下，增加SA或减少CTAB均可获得较好的维持效果，这是由于活性成分与纳米胶囊壳基质之间的相互作用增强。纳米胶囊的掺入使EB活性显著提高。典型正电荷纳米胶囊EB@SA0.1CTAB0.4Tw0.2对分离密蝇幼虫投喂48 h后的中位致死浓度为商业EB-EC的48%。结果表明，SA和CTAB自组装是一种条件温和、效率高、成本低的快速制备纳米制剂的良好策略，对推动纳米农药从实验室研究到现场应用具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.