M. Al-Ghorbani, M. A. Gouda, O. Alharbi, K. A. Al-Mutairi, R. Ramu
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引用次数: 0
Abstract
New classes of N-(4-acetylphenyl)-2-cyanoacetamide analogs were designed and synthesized using the Knoevenagel condensation. The synthesized analogs were characterized using IR, 1H NMR, and 13C NMR analytical techniques. The antimicrobial activities for prepared compounds were established, the compound containing thiazole ring was more active than other compounds against P. aeruginosa, K. pneumonia, E. coli, and E. cloacae, respectively. Furthermore, it showed a more sensitive compound against A549 cell lines. The docking and MD simulation were studied and were in matching with the practical study. Same compound was found to have the most negative binding affinity and bound with streptomycin to DNA gyrase B and the wild-type (apo-structure) of DNA gyrase B.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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