Extraction of Sanguisorba officinalis L. polysaccharide by ultrasound-assisted extraction: structural characterization, antioxidant, hemostatic and immunological activity

IF 8.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry Pub Date : 2025-02-25 DOI:10.1016/j.ultsonch.2025.107292

Shuang Jiang , Xiaotian Wu , Xuepeng Shi , Yuanqiu Mu , Li Zhang , Shulu Zhang , Lin Wei , Zheng Feng , Yinze Zhong , Xinhui Huang , Yeqing Xu , Shah Syed Faizan Ali , Zhaonan Xu , Xiaotong Wang , Chunli Gan , Zhibin Wang , Yanan Sun , Chunjuan Yang

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引用次数: 0

Abstract

Sanguisorba officinalis L. (S. officinalis) has been widely distributed in various regions of China and holds significant potential for various applications. However, limited studies have focused on S. officinalis polysaccharides (SOPs) and their biological activities. Utilizing response surface methodology (RSM), the process of ultrasonic-assisted extraction of SOPs was optimized. The optimal conditions were 270.2 W, 42.4 mL/g, and 47.7 min. Through separation and purification, a neutral polysaccharide named SOUP-1 was obtained. SOUP-1 (17.1 kDa) mainly includes glucose and a few galactose, mannose, and arabinose. The main chain of SOUP-1 is primarily → 4)-α-D-Glcp-(1 → 4,6)-α-D-Glcp-(1 → substituted at C6 with branch chain → 6)-α-D-Glcp-(1 → . Furthermore, SOUP-1 showed antioxidant activity, including scavenging activities of hydroxyl radicals and DPPH. It also enhances macrophage phagocytic activity and modulates the expression of inflammatory cytokines such as TNF-α and IL-6. Additionally, this study first discovered the hemostatic activity of SOUP-1. This study provides theoretical support for the potential applications and further research of SOPs. It provides a basis for the development of SOPs as novel natural-source immunomodulators in the food and pharmaceutical industries.

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来源期刊

Ultrasonics Sonochemistry 化学-化学综合

CiteScore

15.80

自引率

11.90%

发文量

361

审稿时长

59 days

期刊介绍： Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels. Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.