Lumbar spinal stenosis with degenerative spondylolisthesis in twins: An observational study from the national Swedish spine registry and the Swedish twin registry

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Clinical Neuroscience Pub Date : 2025-02-28 DOI:10.1016/j.jocn.2025.111155

Anders Joelson , Lilla Szigethy , Freyr Gauti Sigmundsson

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引用次数: 0

Abstract

Background

Only a few studies have investigated the genetic background of lumbar spinal stenosis (LSS) with degenerative spondylolisthesis (DS) requiring surgery. The purpose of this study was to determine the concordance rates for LSS with DS requiring surgery by studying monozygotic (MZ) and dizygotic (DZ) twin pairs.

Methods

Patients between 18 and 85 years of age who underwent surgery for LSS with DS between 1996 and 2022 were identified in the national Swedish spine registry (14,614 patients) and matched with the Swedish Twin Registry to identify MZ and DZ twins. The concordance rates, the MZ/DZ concordance ratios, and the limits of genetic determination were calculated.

Results

We identified 145 twin pairs (27 MZ and 118 DZ pairs) of whom 1 or both twins underwent surgery for LSS with DS. We found no concordant MZ pair and 2 concordant DZ pairs. When we evaluated pairs where at least one twin was operated for LSS with DS we found 2 concordant MZ pairs and 4 concordant DZ pairs (the co-twins were operated for LSS without DS) resulting in the probandwise concordance rate 0.14 (95% CI, 0 to 0.31) for MZ twins and 0.07 (95% CI, 0.02 to 0.13) for DZ twins. The probandwise MZ/DZ concordance ratio was 2.1 (95% CI 0–11.9). The limits of genetic determination were 0.27 to 0.36.

Conclusions

Our findings suggest that heredity may not be of major etiologic importance in most cases of LSS with DS requiring surgery.

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来源期刊

Journal of Clinical Neuroscience 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

402

审稿时长

40 days

期刊介绍： This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology. The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.