Molecular mechanism of programmed cell death in drug-induced neuronal damage: A special focus on ketamine-induced neurotoxicity

IF 4.8 3区医学 Q1 PHARMACOLOGY & PHARMACY

Toxicology Pub Date : 2025-02-25 DOI:10.1016/j.tox.2025.154102

Peipei Wang , Tong Niu , Degao Huang, Yuanlong Li, Zihan Jiang, Xia Wang, Linchuan Liao

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Abstract

In recent years, the abuse of ketamine as a recreational drug has been growing, and has become one of the most widely abused drugs. Continuous using ketamine poses a risk of drug addiction and complications such as attention deficit disorder, memory loss and cognitive decline. Ketamine-induced neurotoxicity is thought to play a key role in the development of these neurological complications. In this paper, we focus on the molecular mechanisms of ketamine-induced neurotoxicity. According to our analyses, drugs in causing neurotoxicity are closely associated with programmed cell death (PCD) such as apoptosis, autophagy, necroptosis, pyroptosis, and Ferroptosis. Therefore, this review will collate the existing mechanisms of programmed death in ketamine-induced neurotoxicity as well as explore the possible mechanisms by outlining the mechanisms of programmed death in other drug-induced neurotoxicity, which may be helpful in identifying potential therapeutic targets for neurotoxicity induced by ketamine abuse.

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药物性神经元损伤中程序性细胞死亡的分子机制：特别关注氯胺酮诱导的神经毒性

近年来，氯胺酮作为一种消遣性药物的滥用日益严重，已成为滥用最广泛的药物之一。持续使用氯胺酮会带来药物成瘾和并发症的风险，如注意力缺陷障碍、记忆力丧失和认知能力下降。氯胺酮引起的神经毒性被认为在这些神经系统并发症的发展中起着关键作用。本文就氯胺酮引起神经毒性的分子机制作一综述。根据我们的分析，引起神经毒性的药物与程序性细胞死亡（PCD）密切相关，如细胞凋亡、自噬、坏死、焦亡和铁亡。因此，本文将整理氯胺酮致神经毒性程序性死亡的现有机制，并通过概述其他药物致神经毒性程序性死亡的机制来探讨可能的机制，这可能有助于确定氯胺酮滥用致神经毒性的潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicology 医学-毒理学

CiteScore

7.80

自引率

4.40%

发文量

222

审稿时长

23 days

期刊介绍： Toxicology is an international, peer-reviewed journal that publishes only the highest quality original scientific research and critical reviews describing hypothesis-based investigations into mechanisms of toxicity associated with exposures to xenobiotic chemicals, particularly as it relates to human health. In this respect "mechanisms" is defined on both the macro (e.g. physiological, biological, kinetic, species, sex, etc.) and molecular (genomic, transcriptomic, metabolic, etc.) scale. Emphasis is placed on findings that identify novel hazards and that can be extrapolated to exposures and mechanisms that are relevant to estimating human risk. Toxicology also publishes brief communications, personal commentaries and opinion articles, as well as concise expert reviews on contemporary topics. All research and review articles published in Toxicology are subject to rigorous peer review. Authors are asked to contact the Editor-in-Chief prior to submitting review articles or commentaries for consideration for publication in Toxicology.