Investigation of the relationship between Body Mass Index and epilepsy

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-02-28 DOI:10.1016/j.yebeh.2025.110295

Yu-xuan Li , Ruo-xia Chen , Xue-rui Lv , Qiang Zi , Fu-mei Zhang , Yun Li

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Abstract

Objective

To examine the clinical characteristics and influencing factors among epilepsy patients with varying Body Mass Index (BMI), and to propose new approaches for the prevention and treatment of epilepsy.

Methods

A total of 250 adult patients, newly diagnosed with epilepsy and not yet treated with antiepileptic drugs at the First Affiliated Hospital of Dali University between January 2017 and December 2022, were randomly selected as the experimental group. Additionally, 250 healthy individuals from the same period served as the control group to investigate the relationship between BMI and epilepsy. Univariate analysis and ordered multiple logistic regression were used to further identify factors influencing BMI in patients with epilepsy.

Results

A significant difference in BMI was found between adults newly diagnosed with epilepsy who had not yet used antiepileptic drugs, and healthy individuals (P = 0.001). The obesity rate was higher in epilepsy patients (20.4 %) compared to healthy adults (9.6 %).The ordered multiple logistic regression analysis revealed that gender(P = 0.003), age(P = 0.029), nation(P = 0.008), occupation(P < 0.001), etiology(P = 0.001), NLR(P = 0.022), and SIRI(P = 0.008) were all significant factors influencing BMI in epilepsy patients.

Conclusion

People with epilepsy are more likely to also be obese and is associated with factors such as gender, age, nation, occupation, etiology, and inflammatory markers. In clinical practice, it is essential to monitor and manage BMI in epilepsy patients, identify preventable risk factors, and ultimately enhance treatment outcomes and quality of life.

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.