Metastructure and strain-defect engineered Cu-doped TiOx coating to enhance antibacterial sonodynamic therapy

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-02-27 DOI:10.1016/j.bioactmat.2025.02.028

Songsong Wang , Ji Tan , Haifeng Zhang , Shiwei Guan , Yibo Zeng , Xiaoshuang Nie , Hongqin Zhu , Shi Qian , Xuanyong Liu

{"title":"Metastructure and strain-defect engineered Cu-doped TiOx coating to enhance antibacterial sonodynamic therapy","authors":"Songsong Wang , Ji Tan , Haifeng Zhang , Shiwei Guan , Yibo Zeng , Xiaoshuang Nie , Hongqin Zhu , Shi Qian , Xuanyong Liu","doi":"10.1016/j.bioactmat.2025.02.028","DOIUrl":null,"url":null,"abstract":"<div><div>Sonodynamic therapy (SDT) has attracted widespread attention in treatment of implant-associated infections, one of the key factors leading to implant failure. Nevertheless, constructing efficient ultrasound-triggered coatings on implant surfaces remains a challenge. Herein, an acoustic metastructure Cu-doped defective titanium oxide coating (Cu-TiOx) with lattice strain was constructed in situ on titanium implant to realize effective sonocatalysis. The redistribution of Cu atoms broke the pristine lattice of TiO2 during the thermal reduction treatment to regulate its energy structure, which favored separation of electron-hole pairs generated by ultrasound radiation to enhance the sonocatalytic generation of reactive oxygen species. In addition, the acoustic metastructure enhanced the absorption of ultrasound by Cu-TiOx metastructure coating, which further promoted its sonocatalytic effect. Thus, Cu-TiOx metastructure coating could efficiently eliminate Staphylococcus aureus and Escherichia coli infections under ultrasonic irradiation in 10 min. Besides, the osteogenic property of implant was significantly improved after infection clearance in vivo. This work provides a fresh perspective on the design of SDT biosurfaces based on metastructure and strain-defect engineering.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"48 ","pages":"Pages 458-473"},"PeriodicalIF":18.0000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioactive Materials","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452199X25000842","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Sonodynamic therapy (SDT) has attracted widespread attention in treatment of implant-associated infections, one of the key factors leading to implant failure. Nevertheless, constructing efficient ultrasound-triggered coatings on implant surfaces remains a challenge. Herein, an acoustic metastructure Cu-doped defective titanium oxide coating (Cu-TiO_x) with lattice strain was constructed in situ on titanium implant to realize effective sonocatalysis. The redistribution of Cu atoms broke the pristine lattice of TiO₂ during the thermal reduction treatment to regulate its energy structure, which favored separation of electron-hole pairs generated by ultrasound radiation to enhance the sonocatalytic generation of reactive oxygen species. In addition, the acoustic metastructure enhanced the absorption of ultrasound by Cu-TiO_x metastructure coating, which further promoted its sonocatalytic effect. Thus, Cu-TiO_x metastructure coating could efficiently eliminate Staphylococcus aureus and Escherichia coli infections under ultrasonic irradiation in 10 min. Besides, the osteogenic property of implant was significantly improved after infection clearance in vivo. This work provides a fresh perspective on the design of SDT biosurfaces based on metastructure and strain-defect engineering.

Abstract Image

查看原文本刊更多论文

元结构和应变缺陷工程cu掺杂TiOx涂层增强抗菌声动力治疗

声动力疗法（SDT）是导致种植体失败的关键因素之一，在治疗种植体相关性感染方面受到了广泛关注。然而，在植入物表面构建有效的超声触发涂层仍然是一个挑战。本文在钛植入体上原位构建了具有晶格应变的cu掺杂缺陷氧化钛（Cu-TiOx）声超结构涂层，实现了有效的声催化。热还原过程中Cu原子的重分布打破了TiO2的原始晶格，从而调节了其能量结构，有利于超声辐射产生的电子-空穴对的分离，从而增强了活性氧的声催化生成。此外，声元结构增强了Cu-TiOx元结构涂层对超声波的吸收，进一步促进了其声催化效果。由此可见，Cu-TiOx超微结构涂层能在超声照射下10 min内有效消除金黄色葡萄球菌和大肠杆菌感染，并且在体内清除感染后，种植体的成骨性能显著提高。这项工作为基于元结构和应变缺陷工程的SDT生物表面设计提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.