Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 T

IF 1.8 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Open Pub Date : 2025-02-27 DOI:10.1016/j.ejro.2025.100640

Lijing Xin , Philippe Reymond , José Boto , Frederic Grouiller , Serge Vulliemoz , Francois Lazeyras , Maria Isabel Vargas

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Abstract

Background and purpose

This study aims to evaluate the neurochemical characteristics of pathological tissues by ¹H magnetic resonance spectroscopy (MRS) in patient with pharmaco-resistant focal epilepsy at 7 T.

Methods

Thirteen patients with drug-resistant epilepsy and focal seizure successfully underwent MRS examinations at 7 T MRI scanners. ¹H MR spectra were acquired from two voxels (lesion side and contralateral side) using the semi-adiabatic spin-echo full-intensity localized spectroscopy (sSPECIAL) sequence. Metabolite levels were quantified from LCModel and reported as to total creatine ratio.

Results

In comparison to the contralateral side, lesions in focal cortical dysplasia demonstrated significantly reduced macromolecule and N-acetyl aspartate, significantly increased total choline and glycine + myo-inositol, and a distinct reduction trend of glutamate.

Conclusions

We conclude that performing MRS at high magnetic field offered the potential to reveal metabolic alterations in epilepsy lesions that may help to further understand the underlying pathophysiology of the disease.

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