Targeted reversal of iron deposition by highly active manganese-doped carbon dots in MRI-guided treatment of Parkinson's disease

IF 10.5 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Carbon Pub Date : 2025-02-25 DOI:10.1016/j.carbon.2025.120152

Huihui Wang , Maolin Zhang , Dongchuan Chu , Xueping Huang , Yu Shi , Yi Zhao , Hang Qu , Dandan Li , Zhuobin Xu , Xiaohong Wang , Hao Chen , Lizeng Gao , Wei Wang

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引用次数: 0

Abstract

Parkinson's disease is a common neurodegenerative disease, without effective clinical methods, but drugs to slow down the progress. Herein, a manganese-doped carbon dots nanozyme (Mn-CDs) was constructed with the ability of magnetic resonance enhancement and strong property to scavenge reactive oxygen species (ROS). Importantly, after connected to artemisinin (Art) and lactoferrin (Lf), the Art-Mn-CDs@Lf nanozyme could penetrate the blood-brain barrier (BBB) effectively and target the site of iron accumulation in the brain of PD mice, which also enhanced MR imaging of the lesion site. In vitro and in vivo experiments showed that Art-Mn-CDs@Lf could effectively alleviate the highly oxidized microenvironment, protect the mitochondrial dysfunction, reduce the excessive iron deposition, restore the expression of Tyrosine hydroxylase (TH) and misfolding of α-synuclein (α-syn) and alleviate the neuronal damage. This work demonstrates that Art-Mn-CDs@Lf offers great potential for MR imaging guided therapy for Parkinson's disease.

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来源期刊

Carbon 工程技术-材料科学：综合

CiteScore

20.80

自引率

7.30%

发文量

审稿时长

23 days

期刊介绍： The journal Carbon is an international multidisciplinary forum for communicating scientific advances in the field of carbon materials. It reports new findings related to the formation, structure, properties, behaviors, and technological applications of carbons. Carbons are a broad class of ordered or disordered solid phases composed primarily of elemental carbon, including but not limited to carbon black, carbon fibers and filaments, carbon nanotubes, diamond and diamond-like carbon, fullerenes, glassy carbon, graphite, graphene, graphene-oxide, porous carbons, pyrolytic carbon, and other sp2 and non-sp2 hybridized carbon systems. Carbon is the companion title to the open access journal Carbon Trends. Relevant application areas for carbon materials include biology and medicine, catalysis, electronic, optoelectronic, spintronic, high-frequency, and photonic devices, energy storage and conversion systems, environmental applications and water treatment, smart materials and systems, and structural and thermal applications.