Targeting mental health: A scoping review of acupoints selection in acupressure for depression, anxiety, and stress

Abstract

Background

Depression, anxiety, and stress are prevalent mental health conditions that significantly affect global well-being. Conventional treatments, including pharmacological and psychotherapeutic approaches, often have limitations. Acupressure, a Traditional Chinese Medicine (TCM) technique, has gained attention as a complementary, non-invasive therapy. Acupressure stimulates specific acupoints to balance the body’s energy (Qi) and promote relaxation. This scoping review explores the effectiveness of acupressure for managing depression, anxiety, and stress by analyzing the frequency and selection of key acupoints in randomized controlled trials.

Methods

A comprehensive search was conducted in the PubMed database, focusing on RCTs that evaluated acupressure's effects on depression, anxiety, and stress. Studies were screened based on predefined inclusion criteria, including formal diagnoses, well-documented acupressure points, and standardized outcome measures. Data on acupoint usage, meridian applications, and treatment outcomes were also extracted and analyzed.

Results

Nineteen studies met the inclusion criteria, with a median sample size of 58 participants. The analysis highlighted the frequent use of auricular Shenmen (TF4) in treating depression, stress, and combined conditions, while Yintang (EX-HN3) and body acupoint Shenmen (HT7) were prominent for managing anxiety. Auricular points played a central role in stress management, comprising 62.50 % of applications, while body acupoints like Taichong (LV3) and Zusanli (ST36) supported overall emotional balance and physical well-being. Although no significant adverse events were reported, studies often lacked standardized safety reporting and follow-up data.

Conclusion

This review highlights the frequent use of acupoints such as the auricular Shenmen (TF4), as well as body acupoints Yintang (EX-HN3)and Shenmen (HT7) in promoting emotional regulation and stress relief. The integration of auricular and body acupoints, combined with targeted meridians, provides a foundational framework for utilizing acupressure as a complementary therapy for depression, anxiety, and stress.