Sensory neurons on guard: roles in pathogen defense and host immunity

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-02-26 DOI:10.1016/j.coi.2025.102541

Ozge Erdogan , Xiao-Qian Hu , Isaac M Chiu

引用次数: 0

Abstract

The nervous system, like the immune system, constantly interfaces with the environment, encountering threats, including pathogens. Recent discoveries reveal an emerging role for sensory neurons in host defense and immunity. Sensory neurons detect infections either by directly sensing microbial signals or through immune mediators. Beyond pathogen detection, they modulate immune responses and local inflammation by interacting with immune cells, influencing inflammation and pathogen clearance. Additionally, sensory neurons trigger protective reflexes — such as pain, coughing, sneezing, and itching — that can help expel pathogens but may also facilitate their spread. Sensory neurons may also encode and shape long-term immunity. Understanding the roles of neurons in pathogen defense could offer new insights into infectious diseases and highlight therapeutic opportunities for immune modulation.

查看原文本刊更多论文

警觉的感觉神经元：在病原体防御和宿主免疫中的作用

神经系统和免疫系统一样，不断地与环境接触，遇到包括病原体在内的威胁。最近的发现揭示了感觉神经元在宿主防御和免疫中的作用。感觉神经元通过直接感知微生物信号或通过免疫介质检测感染。除了病原体检测外，它们还通过与免疫细胞相互作用，影响炎症和病原体清除来调节免疫反应和局部炎症。此外，感觉神经元会触发保护性反射——比如疼痛、咳嗽、打喷嚏和瘙痒——这有助于驱逐病原体，但也可能促进它们的传播。感觉神经元也可能编码和塑造长期免疫。了解神经元在病原体防御中的作用可以为感染性疾病提供新的见解，并突出免疫调节的治疗机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.