Effects of hyperglycemia and resveratrol on the processes of implant osseointegration and peri-implant bone remodeling: Revealed by non-linear analysis

IF 3 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materialia Pub Date : 2025-03-01 DOI:10.1016/j.mtla.2025.102371

Robert S. Liddell , Suzette Guo , Anthony Staibano , John E. Davies

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Abstract

Hyperglycemia is detrimental to bone healing and quality. Oral administration of resveratrol may have protective effects on bone repair. This study investigated the impact of resveratrol on the bone anchorage of microtopographic or nanotopographic implants placed in the tibiae of hyperglycemic and euglycemic rats.

Blood glucose, body weight, and implant removal torque were measured. Anchorage during the process of osseointegration, and later bone remodeling, were quantified by fitting a biphasic asymptotic curve. We hypothesized that resveratrol would enhance the process of osseointegration and reverse the detrimental effects of hyperglycemia.

Hyperglycemic animals had elevated blood sugar levels and reduced weight gain; neither affected by resveratrol. Nanotopographic implant removal torque was increased by 1.2 times (p = 0.0002, 95 % CI [1.1,1.3]) compared to microtopographic implants. At 84 days, linear modeling indicated that the untreated hyperglycemic groups’ removal torque values were half of the untreated euglycemic groups’ (p = 0.0005, 95 % CI [0.3,0.8]). This reduction in anchorage is associated with less virtual distal implant drift. Resveratrol treatment increased anchorage in hyperglycemic rats by 1.8 times (p = 0.005, 95 % CI [1.1,2.8]), returning measurements to euglycemic levels.

Higher bone anchorage was seen for nanotopographic implants, compared to microtopographic implants during the process of osseointegration, but the nanotopographic surface provided no further advantage during bone remodeling. The hyperglycemic condition significantly reduced bone anchorage at later time points, which was eradicated by resveratrol administration. These results may be explained by hyperglycemia and resveratrol disrupting and recovering microcirculation respectively, indicating that resveratrol affects microcirculation rather than the process of bone remodeling.

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来源期刊

Materialia MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

2.90%

发文量

345

审稿时长

36 days

期刊介绍： Materialia is a multidisciplinary journal of materials science and engineering that publishes original peer-reviewed research articles. Articles in Materialia advance the understanding of the relationship between processing, structure, property, and function of materials. Materialia publishes full-length research articles, review articles, and letters (short communications). In addition to receiving direct submissions, Materialia also accepts transfers from Acta Materialia, Inc. partner journals. Materialia offers authors the choice to publish on an open access model (with author fee), or on a subscription model (with no author fee).