Effects of hyperglycemia and resveratrol on the processes of implant osseointegration and peri-implant bone remodeling: Revealed by non-linear analysis

IF 2.9 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materialia Pub Date : 2025-03-01 DOI:10.1016/j.mtla.2025.102371

Robert S. Liddell , Suzette Guo , Anthony Staibano , John E. Davies

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Abstract

Hyperglycemia is detrimental to bone healing and quality. Oral administration of resveratrol may have protective effects on bone repair. This study investigated the impact of resveratrol on the bone anchorage of microtopographic or nanotopographic implants placed in the tibiae of hyperglycemic and euglycemic rats.

Blood glucose, body weight, and implant removal torque were measured. Anchorage during the process of osseointegration, and later bone remodeling, were quantified by fitting a biphasic asymptotic curve. We hypothesized that resveratrol would enhance the process of osseointegration and reverse the detrimental effects of hyperglycemia.

Hyperglycemic animals had elevated blood sugar levels and reduced weight gain; neither affected by resveratrol. Nanotopographic implant removal torque was increased by 1.2 times (p = 0.0002, 95 % CI [1.1,1.3]) compared to microtopographic implants. At 84 days, linear modeling indicated that the untreated hyperglycemic groups’ removal torque values were half of the untreated euglycemic groups’ (p = 0.0005, 95 % CI [0.3,0.8]). This reduction in anchorage is associated with less virtual distal implant drift. Resveratrol treatment increased anchorage in hyperglycemic rats by 1.8 times (p = 0.005, 95 % CI [1.1,2.8]), returning measurements to euglycemic levels.

Higher bone anchorage was seen for nanotopographic implants, compared to microtopographic implants during the process of osseointegration, but the nanotopographic surface provided no further advantage during bone remodeling. The hyperglycemic condition significantly reduced bone anchorage at later time points, which was eradicated by resveratrol administration. These results may be explained by hyperglycemia and resveratrol disrupting and recovering microcirculation respectively, indicating that resveratrol affects microcirculation rather than the process of bone remodeling.

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高血糖和白藜芦醇对种植体骨整合和种植体周围骨重塑过程的影响：非线性分析揭示

高血糖对骨愈合和骨质量是有害的。口服白藜芦醇可能对骨修复有保护作用。本研究探讨了白藜芦醇对高血糖和正常血糖大鼠胫骨微地形或纳米地形植入物骨锚定的影响。测量血糖、体重和植入物移除扭矩。通过拟合双相渐近曲线来量化骨整合过程中的锚固和随后的骨重塑。我们假设白藜芦醇可以促进骨整合过程并逆转高血糖的有害影响。高血糖动物血糖水平升高，体重增加减少；没有受到白藜芦醇的影响。纳米形貌植入物的移除扭矩比微形貌植入物增加了1.2倍（p = 0.0002, 95% CI[1.1,1.3]）。在第84天，线性模型显示，未经治疗的高血糖组的去除扭矩值是未经治疗的正常血糖组的一半（p = 0.0005, 95% CI[0.3,0.8]）。这种支抗的减少与虚拟远端种植体漂移较少有关。白藜芦醇治疗使高血糖大鼠的锚定增加了1.8倍（p = 0.005, 95% CI[1.1,2.8]），使测量值恢复到正常血糖水平。与微形貌种植体相比，纳米形貌种植体在骨整合过程中具有更高的骨锚定，但在骨重塑过程中纳米形貌表面没有提供进一步的优势。在随后的时间点，高血糖状态显著降低了骨锚定，白藜芦醇可以消除这种情况。这些结果可以解释为高血糖和白藜芦醇分别破坏和恢复微循环，表明白藜芦醇影响微循环而不是骨重塑过程。

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来源期刊

Materialia MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

2.90%

发文量

345

审稿时长

36 days

期刊介绍： Materialia is a multidisciplinary journal of materials science and engineering that publishes original peer-reviewed research articles. Articles in Materialia advance the understanding of the relationship between processing, structure, property, and function of materials. Materialia publishes full-length research articles, review articles, and letters (short communications). In addition to receiving direct submissions, Materialia also accepts transfers from Acta Materialia, Inc. partner journals. Materialia offers authors the choice to publish on an open access model (with author fee), or on a subscription model (with no author fee).