Tracing Impacts of Prenatal Exposure to Bisphenol Analogues on Child Anogenital Distance Development: A Birth-cohort Study

IF 12.2 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2025-02-27 DOI:10.1016/j.jhazmat.2025.137730

Jiaxian Chen, Maohua Miao, Xiuxia Song, Honglei Ji, Hongchao Lian, Yao Chen, Wei Yuan, Ziliang Wang

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引用次数: 0

Abstract

Prenatal exposure to bisphenol analogues (BPs) is increasingly common and may affect children’s reproductive development. However, human evidence is limited and inconsistent. Based on the Shanghai-Minhang Birth Cohort Study that enrolled participants in 2012 at Minhang Maternal and Child Health Hospital in Shanghai, China, we measured BPs in maternal urine samples collected during late pregnancy and children’s anogenital distance (AGD: boys, AGD_AP (anus-penis), AGD_AS (anus-scrotum); girls, AGD_AC (anus-clitoris), AGD_AF (anus-fourchette)) from birth to 48 months as an indicator of reproductive development. A total of 545 mother-child pairs were included. Boys with detected maternal bisphenol A (BPA), bisphenol F (BPF), bisphenol S (BPS) and bisphenol AF (BPAF) tended to have increased AGD_AP at 6 months, while at 12 months, BPA, BPS, and BPAF were associated with a marginal decrease in AGD_AP. In girls, higher levels of BPA, BPF and BPS were associated with longer AGD at 48 months and higher risks of rapid AGD growth. Bayesian kernel machine regression models showed significant associations between BPs mixtures and AGD in both sexes, with BPF and BPS identified as major contributors. Our study revealed the lasting, sex-specific impacts of prenatal exposure to BPA and its alternatives on children’s reproductive development.

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.