Antimicrobial resistant enteric bacteria are widely distributed among environmental water sources in Dhaka, Bangladesh

IF 10.4 1区工程技术 Q1 ENGINEERING, CHEMICAL

npj Clean Water Pub Date : 2025-02-26 DOI:10.1038/s41545-025-00447-5

Nadim Sharif, Rubayet Rayhan Opu, Tama Saha, Afsana Khan, Fuad M. Alzahrani, Meshari A. Alsuwat, Roger Sarín Rivas Suárez, Eduardo Garcia Villena, Khalid J. Alzahrani, Shuvra Kanti Dey

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Abstract

Disposal of antibiotics and antimicrobial-resistant enteric bacteria (ARB) into water from various sources is responsible for maintaining ARB in the environment. Relative prevalence and circulation of ARB may vary across water sources. We hypothesized that these ARBs with different resistance genes are distributed in various freshwater sources and are related to each other. We screened 155 enteric bacterial isolates from eight different water sources in Dhaka. The prevalence of ARB and MDR enteric bacteria in water was significantly associated (p value < 0.05) with the sources. The genotypic analysis of bla_TEM, qnrB, tetA, mcr-1, and sul-1 revealed higher similarity of the isolates from freshwater with previously reported isolates from clinical samples. Water sources with direct exposure to antibiotics had a significantly higher frequency of genotypic and phenotypic resistance. This study calls for continuous monitoring of water sources and strengthening the treatment of antibiotic and ARB-containing effluents in Bangladesh.

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耐抗生素肠道细菌广泛分布在孟加拉国达卡的环境水源中

将抗生素和抗微生物肠道细菌（ARB）从各种来源排入水中是维持环境中ARB的原因。ARB的相对流行率和循环可能因水源而异。我们推测这些具有不同抗性基因的arb分布在不同的淡水资源中，并且相互关联。我们从达卡的8个不同水源中筛选出155株肠道细菌。水中ARB和MDR肠道细菌的患病率与来源有显著相关性（p值<； 0.05）。对blattem、qnrB、tetA、mcr-1和sul1的基因型分析显示，淡水分离株与先前报道的临床分离株具有较高的相似性。直接接触抗生素的水源出现基因型和表型耐药的频率明显较高。这项研究要求对孟加拉国的水源进行持续监测，并加强对抗生素和含arb的污水的处理。

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来源期刊

npj Clean Water Environmental Science-Water Science and Technology

CiteScore

15.30

自引率

2.60%

发文量

审稿时长

5 weeks

期刊介绍： npj Clean Water publishes high-quality papers that report cutting-edge science, technology, applications, policies, and societal issues contributing to a more sustainable supply of clean water. The journal's publications may also support and accelerate the achievement of Sustainable Development Goal 6, which focuses on clean water and sanitation.