Peripapillary atrophy in patients with birdshot chorioretinitis

IF 3.7 2区医学 Q1 OPHTHALMOLOGY

British Journal of Ophthalmology Pub Date : 2025-02-26 DOI:10.1136/bjo-2024-326440

Thomas Ferreira de Moura, Aurélie Enjalbert, Dominique Monnet, Souhila Kecili, Linda Imikerene, Jordan Loeliger, Jennifer E Thorne, Antoine P Brézin

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引用次数: 0

Abstract

Aims This study aims to analyse peripapillary atrophy (PPA), its frequency, extent and relation with measures of visual function in patients with birdshot chorioretinitis (BSCR). Methods Patients of the single-centre prospective COhort of patients with BIRDshot chorioretinitis (ClinicalTrials.gov Identifier: [NCT05153057][1]) were included. The areas of the optic nerve head (ONH) and PPA were measured on red–green and autofluorescence fundus images acquired by ultrawidefield retinal photography. The main outcome measure was the frequency of PPA. Correlations between the PPA/ONH ratio and disease duration, age, best corrected visual acuity (BCVA) and visual field results (mean deviation (MD) and the pattern SD (PSD)—Humphrey perimeter 30–2) were evaluated using the Spearman coefficient. Results A total of 752 eyes from 384 patients (mean age 62.4±12.1 years) were included. The median disease duration was 13.0 (7.0–19.0) years. PPA was observed in 717 (95.4%) eyes. The mean PPA/ONH ratio was 2.9±2.2 on red–green images, 3.1±2.2 on autofluorescence, and these measures were highly correlated (R=0.95, p<0.0001). The ratio of PPA/ONH increased with the duration of the disease (R=0.57, p<0.0001) from 1.6±0.6 in the 0–5 years group to 5.2±2.9 after 25 years and with age (R=0.51, p<0.0001). PPA was also associated with a worse BCVA (R=−0.42, p<0.0001) and worse visual field results: MD (R=−0.41, p<0.0001), PSD (R=0.42, p<0.0001). A strong intereye symmetry of the PPA/ONH ratio was observed (R=0.91, p<0.0001), which was greater than that of BCVA (R=0.58, p<0.0001), MD (R=0.76, p<0.0001) or PSD (R=0.70, p<0.0001). Conclusions Almost all patients with BSCR exhibit PPA and its extent increases over time. PPA is associated with poorer vision. All data relevant to the study are included in the article or uploaded as supplementary information. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT05153057&atom=%2Fbjophthalmol%2Fearly%2F2025%2F02%2F26%2Fbjo-2024-326440.atom

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鸟射性脉络膜视网膜炎患者乳头周围萎缩

目的分析鸟状脉络膜视网膜炎（BSCR）患者乳头周围萎缩（PPA）的发生频率、程度及其与视功能指标的关系。方法纳入BIRDshot脉络膜视网膜炎患者的单中心前瞻性队列（ClinicalTrials.gov识别号：[NCT05153057][1]）。采用超宽视场视网膜摄影，在眼底红绿和自身荧光图像上测量视神经头（ONH）和PPA的面积。主要结局指标是PPA的频率。采用Spearman系数评价PPA/ONH比值与病程、年龄、最佳矫正视力（BCVA）和视野结果（平均偏差（MD）和模式SD (PSD) -Humphrey周长30-2）的相关性。结果共纳入384例患者752只眼，平均年龄62.4±12.1岁。中位病程为13.0（7.0-19.0）年。717只（95.4%）眼出现PPA。红绿图像PPA/ONH的平均值为2.9±2.2，自体荧光图像PPA/ONH的平均值为3.1±2.2，两者高度相关（R=0.95, p<0.0001）。PPA/ONH比值随病程的延长而增加（R=0.57, p<0.0001），由0 ~ 5岁组的1.6±0.6增加到25岁组的5.2±2.9 （R=0.51, p<0.0001）。PPA还与较差的BCVA （R= - 0.42, p<0.0001）和较差的视野结果相关：MD (R= - 0.41, p<0.0001), PSD （R=0.42, p<0.0001）。PPA/ONH比值具有较强的眼间对称性（R=0.91, p<0.0001），优于BCVA （R=0.58, p<0.0001）、MD （R=0.76, p<0.0001）和PSD （R=0.70, p<0.0001）。结论：几乎所有BSCR患者均表现为PPA，且其程度随时间增加。PPA与视力较差有关。所有与研究相关的数据都包含在文章中或作为补充信息上传。[1]: /查找/ external-ref ? link_type = CLINTRIALGOV&access_num = NCT05153057&atom = % 2 fbjophthalmol % 2恐惧% 2 f2025 % 2 f02 % 2 f26 % 2 fbjo - 2024 - 326440. -原子

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来源期刊

British Journal of Ophthalmology 医学-眼科学

CiteScore

10.30

自引率

2.40%

发文量

213

审稿时长

3-6 weeks

期刊介绍： The British Journal of Ophthalmology (BJO) is an international peer-reviewed journal for ophthalmologists and visual science specialists. BJO publishes clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology. It also provides major reviews and also publishes manuscripts covering regional issues in a global context.