Silent Threat: Fatal Consequences of Occult Hepatitis C Viral Infection in a Kidney Transplant Recipient: A Case Report and Literature Review

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2025-02-25 DOI:10.1016/j.transproceed.2025.02.006

Hany M. El Hennawy , Abelaziz A. Abdelaziz , Yasser Mansour , Mohammad F. Zaitoun , Ibrahim Tawhari , Omar Safar , Rafaat M. Chakik , Mosa A. Fagih , Abdullah S. Al Faifi

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引用次数: 0

Abstract

We present the case of a 54-year-old female patient with a history of treated hepatitis B who underwent living-related kidney transplantation from her son. The timing of the transplantation and immediate postoperative period was uneventful, with no significant complications. However, within 3 months, she was repeatedly hospitalized because of persistent jaundice, abdominal pain, and diarrhea, and liver function tests indicated considerable liver injury. Extensive investigations have revealed an occult hepatitis C virus infection that occurred before transplantation. The patient subsequently developed acute fulminant liver failure accompanied by severe gastrointestinal bleeding. Despite aggressive medical management, her condition deteriorated rapidly, leading to death. This case underscores the importance of comprehensive viral screening in transplant recipients, particularly those with risk factors or symptoms of hepatitis C virus infection, to prevent potentially life-threatening complications following transplantation.

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无声的威胁：肾移植受者隐性丙型肝炎病毒感染的致命后果：一例报告和文献综述。

我们提出的情况下，54岁的女性患者治疗史乙型肝炎谁接受活体肾移植从她的儿子。移植的时间和术后的时间是平稳的，没有明显的并发症。然而，在3个月内，由于持续的黄疸、腹痛和腹泻，她多次住院，肝功能检查显示严重的肝损伤。广泛的调查显示，移植前曾发生隐匿性丙型肝炎病毒感染。患者随后发展为急性暴发性肝功能衰竭并伴有严重的胃肠道出血。尽管进行了积极的医疗管理，但她的病情迅速恶化，导致死亡。该病例强调了对移植受者进行全面病毒筛查的重要性，特别是那些有丙型肝炎病毒感染危险因素或症状的人，以预防移植后可能危及生命的并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.