Hyperspectral Imaging of Uterine Fibroids

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
Aidan M. Therien, Jonah A. Majumder, Arielle S. Joasil, Daniella M. Fodera, Kristin M. Myers, Xiaowei Chen, Christine P. Hendon
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引用次数: 0

Abstract

Uterine fibroids are non-cancerous growths of the uterus that affect nearly 70%–80% of women in their lifetimes. Fibroids can cause severe pain, bleeding, and infertility. The main risk of recurrence is smaller fibroids, which are notoriously hard to detect, being missed during a surgical removal procedure, only to enlarge afterwards. In this work, hyperspectral imaging (HSI) datasets were acquired from samples from 10 patients after receiving a hysterectomy. Optical properties including absorption, scattering, and spectral morphology were extracted and fed into machine learning to classify regions as fibroid and myometrium. Top extracted optical features had significant contrast between fibroid and myometrium (p < 0.0001) and were used to train Random Forest (AUC: 0.9985 ± 0.001, Sensitivity: 0.9534 ± 0.019, Specificity: 0.9936 ± 0.009) and Logistic Regression (AUC: 0.9397 ± 0.013, Sensitivity: 0.8405 ± 0.023, Specificity: 0.8895 ± 0.032) with strong performance across testing splits. With HSI, there is contrast between fibroid and myometrium in the human uterus.

Abstract Image

子宫肌瘤的高光谱成像。
子宫肌瘤是子宫的非癌性生长,影响了近70%-80%的女性。肌瘤会引起剧烈的疼痛、出血和不孕。复发的主要风险是较小的肌瘤,这是出了名的难以发现的,在手术切除过程中被遗漏,之后只会扩大。在这项工作中,高光谱成像(HSI)数据集从接受子宫切除术后的10例患者的样本中获得。包括吸收、散射和光谱形态在内的光学特性被提取并输入到机器学习中,以将区域分类为肌瘤和肌层。肌瘤与子宫肌层的上提取光学特征对比显著(p
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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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