Herbicide-related health risks: key mechanisms and a guide to mitigation strategies.

IF 2.9 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Juthamas Hongoeb, Tanawut Tantimongcolwat, Francis Ayimbila, Waralee Ruankham, Kamonrat Phopin
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引用次数: 0

Abstract

Background: Herbicides are a group of substances used to control undesired vegetation in both agricultural and non-agricultural settings. They are recorded as the most consumed class among other pesticides, reaching nearly two million tons worldwide. Despite their effectiveness in weed control, the extensive utilization of herbicides has raised concerns regarding adverse effects on human health. However, comprehensive reviews addressing herbicide-related human health risks remain limited. This work aims to compile scientific evidence and possible underlying mechanisms to emphasize the hazards that need to be acknowledged, as well as to explore novel strategies for minimizing the impact on human health.

Method: Scientific data on herbicide-related human health risks, including human-related data and non-human experimental research, were retrieved from databases such as PubMed, Scopus, and Google Scholar. Pre-determined eligibility criteria were applied to select the final studies.

Result: A narrative summary of evidence-based human incidence and laboratory experiments is presented to organize and highlight key findings. This indicates the life-threatening nature of herbicide exposure in humans, ranging from acute toxicity to the development of chronic diseases at any stage of life.

Conclusion: Herbicidal chemicals can harm individuals through various pathways, especially by inducing oxidative stress or directly disrupting molecular and cellular processes. Despite some conflicting findings, effective mitigation strategies are urgently needed to promote a safer society and protect human well-being.

与除草剂有关的健康风险:主要机制和缓解战略指南。
背景:除草剂是一组用于控制农业和非农业环境中不受欢迎的植被的物质。它们被记录为其他农药中消费量最大的一类,在全球达到近200万吨。尽管除草剂在控制杂草方面很有效,但它的广泛使用引起了人们对其对人类健康不利影响的关注。然而,针对与除草剂有关的人类健康风险的全面审查仍然有限。这项工作旨在收集科学证据和可能的潜在机制,以强调需要承认的危害,并探索将对人类健康的影响降至最低的新战略。方法:从PubMed、Scopus和谷歌Scholar等数据库中检索除草剂相关人类健康风险的科学数据,包括人类相关数据和非人类实验研究数据。采用预先确定的资格标准来选择最终研究。结果:对基于证据的人类发病率和实验室实验进行了叙述总结,以组织和突出关键发现。这表明人类接触除草剂具有威胁生命的性质,从急性毒性到生命任何阶段的慢性疾病发展。结论:除草化学物质可通过多种途径对人体产生危害,特别是通过诱导氧化应激或直接破坏分子和细胞过程。尽管一些调查结果相互矛盾,但迫切需要有效的缓解战略,以促进更安全的社会和保护人类福祉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Occupational Medicine and Toxicology
Journal of Occupational Medicine and Toxicology PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
6.00
自引率
0.00%
发文量
23
审稿时长
19 weeks
期刊介绍: Aimed at clinicians and researchers, the Journal of Occupational Medicine and Toxicology is a multi-disciplinary, open access journal which publishes original research on the clinical and scientific aspects of occupational and environmental health. With high-quality peer review and quick decision times, we welcome submissions on the diagnosis, prevention, management, and scientific analysis of occupational diseases, injuries, and disability. The journal also covers the promotion of health of workers, their families, and communities, and ranges from rehabilitation to tropical medicine and public health aspects.
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