Exploring the Validity of Measures of Health-Related Quality of Life in Older Adults at Increased Risk of Falls and/or Fractures in Exercise Clinical Trials.

IF 2 3区医学 Q2 GERONTOLOGY

Journal of Applied Gerontology Pub Date : 2025-10-01 Epub Date: 2025-02-26 DOI:10.1177/07334648251316633

Carrie-Anne Ng, Brendan Mulhern, Akanksha Akanksha, Mina Bahrampour, Paul Jansons, Jakub Mesinovic, Anoohya Gandham, Costas Glavas, Peter R Ebeling, Rosalie Viney, David Scott

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Abstract

Exercise targeting physical function and body composition may mitigate falls and fracture risk among older adults. This study aimed to identify the most valid instrument(s) to assess quality of life (QoL) in this context by comparing the psychometric properties of the EQ-5D-3L, EQ-5D-5L, CDC Healthy Days measure, Modified Falls Efficacy Scale (MFES), and Work Productivity and Activity Impairment Questionnaire. Data from four exercise trials (n = 210, mean age 64.8 ± 7.4, 79.0% female) were analyzed. Construct validity and responsiveness were compared. There was moderate to strong convergence between the EQ-5D (-3L and -5L) and MFES, and EQ-5D-3L and CDC index (correlation: 0.45-0.61). Only the EQ-5D-3L demonstrated good known-group validity (effect size: 0.98-3.7). Responsiveness was low across all instruments (standardized response mean: -0.33-0.49). The instruments are valid for assessing QoL in older adults at risk of falls and/or fractures. However, variation in their psychometric properties should be considered when selecting instruments for exercise trials.

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在运动临床试验中探索老年人跌倒和/或骨折风险增加的健康相关生活质量测量的有效性

针对身体功能和身体成分的锻炼可以减轻老年人跌倒和骨折的风险。本研究旨在通过比较EQ-5D-3L、EQ-5D-5L、CDC健康日量表、改良跌倒效能量表（MFES）和工作效率和活动障碍问卷的心理测量特性，确定在这种情况下评估生活质量（QoL）的最有效工具。分析了4项运动试验的数据（n = 210，平均年龄64.8±7.4，女性79.0%）。比较构念效度和反应性。EQ-5D （-3L和-5L）与MFES、EQ-5D-3L与CDC指数之间存在中强趋同（相关系数：0.45-0.61）。只有EQ-5D-3L表现出良好的已知组效度（效应量：0.98-3.7）。所有工具的反应性都很低（标准化反应平均值：-0.33-0.49）。该仪器可有效评估有跌倒和/或骨折风险的老年人的生活质量。然而，在选择运动试验工具时，应考虑他们心理测量特性的变化。

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来源期刊

Journal of Applied Gerontology GERONTOLOGY-

CiteScore

5.10

自引率

13.30%

发文量

202

期刊介绍： The Journal of Applied Gerontology (JAG) is the official journal of the Southern Gerontological Society. It features articles that focus on research applications intended to improve the quality of life of older persons or to enhance our understanding of age-related issues that will eventually lead to such outcomes. We construe application broadly and encourage contributions across a range of applications toward those foci, including interventions, methodology, policy, and theory. Manuscripts from all disciplines represented in gerontology are welcome. Because the circulation and intended audience of JAG is global, contributions from international authors are encouraged.