Skin Barrier in Normal and Allergic Horses: What Do We Know?

IF 2 2区 农林科学 Q2 VETERINARY SCIENCES
Rosanna Marsella
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Abstract

Information on skin barrier in horses is limited. A study on the epidermal ultrastructure of normal and allergic horses documented disorganized amorphous intercellular lipids in the stratum corneum of allergic samples. These findings are similar to atopic canine and human skin. Currently, there is no published study comparing skin barrier function parameters between normal and allergic horses; thus, the functional implications of the ultrastructural changes are unknown. In normal horses, body location, gender, breed, and ambient conditions affect skin barrier parameters, such as Transepidermal Water Loss. Skin microbiome studies on normal horses have highlighted the importance of season and environmental conditions, since horses housed together share similar microbiomes. Skin dysbiosis and predominance of staphylococcus have been described in horses with pastern dermatitis. Transcriptomic studies of the epidermis of normal and allergic horses have found that lesional allergic skin has substantial transcriptomic differences when compared with healthy skin, namely downregulation of genes of tight junctions, keratins, and upregulation of serine proteases and IL-13. Keratinocytes harvested from horses with insect bite hypersensitivity show upregulation of IL-31 gene expression under stimulation. While more research is clearly needed, preliminary results seem to support skin barrier differences between normal and allergic horses.

正常和过敏马的皮肤屏障:我们知道什么?
关于马皮肤屏障的信息是有限的。对正常马和过敏马表皮超微结构的研究表明,过敏样本角质层中存在无序无定形的细胞间脂质。这些发现与狗和人类皮肤的特应性相似。目前,还没有发表的研究比较正常和过敏马的皮肤屏障功能参数;因此,超微结构变化的功能含义尚不清楚。在正常的马中,身体位置、性别、品种和环境条件会影响皮肤屏障参数,如经皮失水。对正常马的皮肤微生物组研究强调了季节和环境条件的重要性,因为住在一起的马有相似的微生物组。皮肤失调和葡萄球菌的优势已经描述了马匹与粘滞性皮炎。对正常和过敏马表皮的转录组学研究发现,病变性过敏皮肤与健康皮肤相比存在显著的转录组学差异,即紧密连接基因、角蛋白基因下调,丝氨酸蛋白酶和IL-13基因上调。从虫咬过敏的马身上采集的角化细胞在刺激下显示IL-31基因表达上调。虽然显然需要更多的研究,但初步结果似乎支持正常马和过敏马之间皮肤屏障的差异。
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来源期刊
Veterinary Sciences
Veterinary Sciences VETERINARY SCIENCES-
CiteScore
2.90
自引率
8.30%
发文量
612
审稿时长
6 weeks
期刊介绍: Veterinary Sciences is an international and interdisciplinary scholarly open access journal. It publishes original that are relevant to any field of veterinary sciences, including prevention, diagnosis and treatment of disease, disorder and injury in animals. This journal covers almost all topics related to animal health and veterinary medicine. Research fields of interest include but are not limited to: anaesthesiology anatomy bacteriology biochemistry cardiology dentistry dermatology embryology endocrinology epidemiology genetics histology immunology microbiology molecular biology mycology neurobiology oncology ophthalmology parasitology pathology pharmacology physiology radiology surgery theriogenology toxicology virology.
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