Altered Volumes of the Amygdala and Hippocampus in the Brain of Suicidal Patients with First Episode Schizophrenia.

IF 2.7 4区 医学 Q2 PSYCHIATRY
Meltem Sen, Nesrin Karamustafalioglu, Pinar Celikkiran, Gamze Ansen, Bayram Ufuk Sakul, Mustafa Nuray Namlı, Umit Haluk Yesilkaya
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引用次数: 0

Abstract

Suicide remains a significant cause of premature death in schizophrenia patients. Structural alterations in the brain and neurobiological mechanisms behind suicidal behavior (SB) in first-episode schizophrenia (FES) have received increasing attention. The amygdala and hippocampus regulate behaviors such as risk-taking, impulsivity, and emotional processing. Abnormalities in these regions have been linked with suicidal ideation, behavior, and psychotic symptoms. However, the association remains unclear. The study included 20 FES patients with current SB, 51 FES patients without SB, and 42 healthy controls. All patients were subjected to clinical evaluations to assess psychotic symptoms and suicidal ideation and behavior, both current and lifetime. T1-weighted magnetic resonance imaging scans were processed through two web-based automatic analysis tools, MRICloud, and volBrain. Bilateral amygdala volumes were found to be significantly lower in the patient groups, while schizophrenia and suicidal ideation had opposite effects on amygdala volumes. Hippocampal subfields such as the right Cornu Amnonis (CA) fields varied according to the clinical status of the patients, including the severity of suicidal ideation and behavior. These findings support not only the involvement of the amygdala and hippocampus in SB and schizophrenia but also their roles in the discrimination of SB in patients with schizophrenia.

首发精神分裂症自杀患者大脑杏仁核和海马体体积的改变
自杀仍然是精神分裂症患者过早死亡的一个重要原因。首发精神分裂症(FES)的脑结构改变和自杀行为(SB)背后的神经生物学机制受到越来越多的关注。杏仁核和海马体调节冒险、冲动和情绪处理等行为。这些区域的异常与自杀意念、行为和精神病症状有关。然而,两者之间的联系尚不清楚。该研究包括20例伴有SB的FES患者,51例无SB的FES患者和42名健康对照。所有患者均接受临床评估,以评估精神病症状、自杀意念和行为,包括当前和终生。t1加权磁共振成像扫描通过两个基于网络的自动分析工具MRICloud和volBrain进行处理。双侧杏仁核体积在患者组中显著降低,而精神分裂症和自杀意念对杏仁核体积的影响相反。海马子区(如右侧角状皮质区)根据患者的临床状态,包括自杀意念和行为的严重程度而变化。这些发现不仅支持杏仁核和海马体参与SB和精神分裂症,而且支持它们在精神分裂症患者对SB的辨别中所起的作用。
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来源期刊
Psychiatric Quarterly
Psychiatric Quarterly PSYCHIATRY-
CiteScore
8.10
自引率
0.00%
发文量
40
期刊介绍: Psychiatric Quarterly publishes original research, theoretical papers, and review articles on the assessment, treatment, and rehabilitation of persons with psychiatric disabilities, with emphasis on care provided in public, community, and private institutional settings such as hospitals, schools, and correctional facilities. Qualitative and quantitative studies concerning the social, clinical, administrative, legal, political, and ethical aspects of mental health care fall within the scope of the journal. Content areas include, but are not limited to, evidence-based practice in prevention, diagnosis, and management of psychiatric disorders; interface of psychiatry with primary and specialty medicine; disparities of access and outcomes in health care service delivery; and socio-cultural and cross-cultural aspects of mental health and wellness, including mental health literacy. 5 Year Impact Factor: 1.023 (2007) Section ''Psychiatry'': Rank 70 out of 82
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