Taciane Maria Melges Pejon, Leonardo Henrique Dalcheco Messias, Rafael Henrique de Oliveira Nascimento, Vanessa Bertolucci, André Felipe Ninomiya, Wladimir Rafael Beck
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引用次数: 0
Abstract
Purpose: Hypoestrogenism is associated with loss of bone mass and strength. Melatonin has become a strategy due to its actions on bone tissue. This review summarizes the available data on the effects of chronic melatonin administration on bone tissue in animal models with hypoestrogenism.
Data sources: A systematic search of the PubMed, Web of Science, and Scopus, databases up to November 27, 2023, was conducted using specified key terms and Boolean operators (bone AND bones OR bone density OR bone diseases OR osteogenesis OR osteoporosis AND melatonin).
Study selection: only controlled studies in English and with rodents.
Study design: systematic review.
Data extraction: animals' characteristics (sex and hypoestrogenism confirmation), dose, route, and duration of administration of melatonin, and outcomes from the properties of bone.
Results: A total of 25 studies were identified after the screening process. In the hypoestrogenic state, melatonin administration improved bone mineral density, bone volume ratio, trabecular number in 19 studies, and maximal load/strength and stiffness test in 7. 4 studies reported improved matrix mineralization in bone marrow mesenchymal stem cells. Melatonin increased the expression of RUNX2 in 9 studies, OCN in 6, and OPG in 4, while decreasing RANKL in 3. In 4 studies the melatonin increased the serum osteocalcin levels.
Conclusion: Chronic administration of melatonin appears to improve the biophysical, biomechanical, molecular, and biochemical properties of bone tissue. These benefits promote an osteogenic effect, making melatonin an efficient strategy to preserve microarchitecture and tissue mass in a state of hypoestrogenism.
目的：雌激素水平低下与骨量和强度的损失有关。褪黑素因其对骨组织的作用而成为一种策略。本文综述了慢性褪黑素对低雌激素动物模型骨组织影响的现有数据。数据来源：系统检索PubMed， Web of Science和Scopus数据库，截止到2023年11月27日，使用指定的关键术语和布尔运算符（骨与骨或骨密度或骨病或成骨或骨质疏松和褪黑激素）进行。研究选择：仅用英语和啮齿类动物进行对照研究。研究设计：系统评价。数据提取：动物特征（性别和雌激素水平低下的确认），褪黑激素的剂量、途径和给药时间，以及骨骼特性的结果。结果：在筛选过程中，共确定了25项研究。在低雌激素状态下，服用褪黑激素改善了19项研究中的骨密度、骨体积比、小梁数，以及7项研究中的最大负荷/强度和刚度测试。4项研究报道了骨髓间充质干细胞基质矿化的改善。褪黑素增加RUNX2的研究有9项，OCN的研究有6项，OPG的研究有4项，降低RANKL的研究有3项。在4项研究中，褪黑素增加了血清骨钙素水平。结论：长期服用褪黑素可以改善骨组织的生物物理、生物力学、分子和生化特性。这些益处促进了成骨作用，使褪黑激素成为一种有效的策略，以保持微结构和组织质量处于低雌激素状态。
期刊介绍：
Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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