The predictive value of the aspartate aminotransferase to platelet ratio index combined with liver biochemical indexes for 2 years native liver survival in patients with biliary atresia.

IF 1.5 3区医学 Q2 PEDIATRICS

Pediatric Surgery International Pub Date : 2025-02-26 DOI:10.1007/s00383-025-05986-z

Bingliang Li, Yingyu Jia, Hongwei Xi, Hongxia Ren

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引用次数: 0

Abstract

Objective: To investigate the predictive value of the aspartate aminotransferase-to-platelet ratio index (APRI) in combination with liver biochemical indices on the time to native liver survival (NLS) in patients with biliary atresia (BA) two years after Kasai portoenterostomy (KPE).

Methods: The clinical data from 2013 to 2022 at Shanxi Children's Hospital were analyzed. Patients were divided into two groups based on whether they survived with their native liver 2 years after KPE. General information and laboratory findings were reviewed before and then monthly after KPE until 3 months postoperatively. APRI was calculated.

Results: A total of 125 children with type III BA were included. There were statistically significant differences in the preoperative AST, GGT, APRI, liver fibrosis stage and jaundice clearance rate between two groups. The AUC of APRI at 3 months for predicting NLS was 0.732. The AUC of APRI at 3 months in predicting the 2-year NLS time in children with BA was higher than the single index.

Conclusion: The prediction value of APRI for 2-year NLS time increases when combined with other indicators, and is better than single indicator, the prediction value is strongest when APRI is combined with all indicators.

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天冬氨酸转氨酶血小板比值指数联合肝脏生化指标对胆道闭锁患者2年原生肝脏生存的预测价值

目的：探讨天冬氨酸转氨酶与血小板比值指数（APRI）联合肝脏生化指标对胆道闭锁（BA）患者开赛门肠造口术（KPE）术后2年天然肝生存时间（NLS）的预测价值。方法：对山西省儿童医院2013 - 2022年的临床资料进行分析。根据患者在KPE后2年的生存情况将患者分为两组。在KPE术前和术后3个月复查一般信息和实验室结果。计算APRI。结果：共纳入125例III型BA患儿。两组患者术前AST、GGT、APRI、肝纤维化分期、黄疸清除率比较，差异均有统计学意义。预测NLS的APRI 3个月AUC为0.732。3个月时APRI的AUC预测BA患儿2年NLS时间高于单一指标。结论：APRI与其他指标联合使用对2年NLS时间的预测价值增加，且优于单一指标，其中APRI与所有指标联合使用时预测价值最强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Surgery International 医学-外科

CiteScore

3.00

自引率

5.60%

发文量

215

审稿时长

3-6 weeks

期刊介绍： Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children. The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include: -Review articles- Original articles- Technical innovations- Letters to the editor