Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study.

IF 1.7 4区 医学 Q3 CLINICAL NEUROLOGY
Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI:10.1080/01616412.2025.2470712
Ali Mojaver, Mojtaba Khazaei, Mohammad Ahmadpanah, Mohammad Zarei, Sara Soleimani Asl, Parisa Habibi, Siamak Shahidi
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引用次数: 0

Abstract

Objectives: Ischemic stroke is one of the most common neurological disorders. Oxidative stress, inflammation, and the reduction of Brain-Derived Neurotrophic Factor (BDNF) are implicated in cell death during ischemic stroke. Several studies suggest that Coenzyme Q10 (CoQ10) has antioxidant, anti-inflammatory, neuroprotective properties and can increase BDNF levels. This study investigated the effects of oral CoQ10 supplementation on oxidative stress biomarkers Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD), Malondialdehyde (MDA), Total Thiol Groups (TTG) - as well as serum levels of Interleukin-6 (IL-6) and BDNF in ischemic stroke patients.

Methods: Fifty patients hospitalized for acute ischemic stroke were randomly divided into two groups: placebo (n = 25) and CoQ10 (600 mg/day) supplementation (n = 25). The intervention began 24 hours after stroke onset and continued for 30 days.

Results: Significant reductions in serum MDA and IL-6 levels, alongside increased SOD and BDNF levels, were observed in the CoQ10 group. No significant differences were found in TAC or TTG levels between the groups.

Conclusions: A 30-day regimen of CoQ10 (600 mg/day) resulted in reduced oxidative stress and inflammation, alongside increased BDNF, suggesting potential neuroprotective benefits for post-stroke rehabilitation. CoQ10 May be considered a therapeutic option for enhancing neuroprotection and rehabilitation in stroke patients.

膳食摄入辅酶Q10可降低急性缺血性卒中患者的氧化应激:一项双盲、随机安慰剂对照研究
目的:缺血性脑卒中是最常见的神经系统疾病之一。氧化应激、炎症和脑源性神经营养因子(BDNF)的减少与缺血性中风期间的细胞死亡有关。一些研究表明辅酶Q10 (CoQ10)具有抗氧化、抗炎、神经保护特性,并能增加BDNF水平。本研究探讨了口服辅酶q10对缺血性卒中患者氧化应激生物标志物总抗氧化能力(TAC)、超氧化物歧化酶(SOD)、丙二醛(MDA)、总硫醇(TTG)以及血清白细胞介素-6 (IL-6)和BDNF水平的影响。方法:50例急性缺血性脑卒中住院患者随机分为安慰剂组(n = 25)和辅酶q10 (600 mg/d)补充组(n = 25)。干预在中风发作后24小时开始,持续30天。结果:CoQ10组血清MDA和IL-6水平显著降低,SOD和BDNF水平升高。两组间TAC或TTG水平无显著差异。结论:CoQ10 (600 mg/天)30天的治疗方案可减少氧化应激和炎症,同时增加BDNF,提示中风后康复可能具有神经保护作用。辅酶q10可能被认为是增强脑卒中患者神经保护和康复的一种治疗选择。
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来源期刊
Neurological Research
Neurological Research 医学-临床神经学
CiteScore
3.60
自引率
0.00%
发文量
116
审稿时长
5.3 months
期刊介绍: Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.
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