Medial temporal lobotomy in the treatment of medial temporal lobe epilepsy: a case series of 12 patients.

IF 2.5 3区医学 Q2 CLINICAL NEUROLOGY

Neurosurgical Review Pub Date : 2025-02-26 DOI:10.1007/s10143-025-03414-3

Jingyi Yang, Yixuan Zhou, Yuankun Cai, Lei Shen, Yuanyuan Ruan, Songshan Chai, Dongyuan Xu, Jianzhang Pu, Hao Du, Nanxiang Xiong

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引用次数: 0

Abstract

Purpose: This case series aimed to investigate the safety and efficacy of medial temporal lobotomy (MTL) in the treatment of medial temporal lobe epilepsy (MTLE).

Methods: We presented our experience with 12 MTLE patients who underwent MTL in our center from January 2018 to July 2021. The MTL technique involves suction-based removal of the amygdala, effectively severing the fibrous connections between the medial temporal lobe structures and the surrounding cortex while maintaining the integrity of the medial temporal lobe structures without removing the hippocampus as in selective amygdalohippocampectomy.

Results: Among the 12 MTLE patients, five were men and seven were women. Mean age was 18.7 years-old, ranging from 6 to 41 years-old. All surgeries were completed successfully. Although one patient developed a transient mild disturbance of consciousness that fully resolved, no patient experienced intracranial hemorrhage, cerebral infarction, hemiplegia, aphasia, or visual field defect. Mean follow-up was 3.25 years, ranging from 6 to 41 years. The Engel classification for seizure outcomes at the last follow-up was as follows: class I, 9 patients (75.0%); class II, 1 patient (8.3%); and class III, 2 patients (16.7%).

Conclusion: Our preliminary results show that MTL is safe and effective. Future studies are warranted to validate our outcomes.

查看原文本刊更多论文

内侧颞叶切除术治疗内侧颞叶癫痫：附12例病例分析。

目的：本病例系列旨在探讨内侧颞叶切除术（MTL）治疗内侧颞叶癫痫（MTLE）的安全性和有效性。方法：我们介绍了2018年1月至2021年7月在我们中心接受MTL的12例MTLE患者的经验。MTL技术包括以吸力为基础的杏仁核切除，有效地切断内侧颞叶结构与周围皮层之间的纤维连接，同时保持内侧颞叶结构的完整性，而不像选择性杏仁核海马切除术那样切除海马。结果：12例MTLE患者中，男性5例，女性7例。平均年龄18.7岁，年龄6 ~ 41岁。所有手术均顺利完成。虽然有一名患者出现短暂的轻度意识障碍，但完全消失，没有患者出现颅内出血、脑梗死、偏瘫、失语或视野缺损。平均随访时间3.25年，6 ~ 41年不等。末次随访时癫痫发作结局的Engel分类如下：I类9例（75.0%）；II类，1例（8.3%）；III级2例（16.7%）。结论：我们的初步结果表明MTL是安全有效的。未来的研究有必要验证我们的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurosurgical Review 医学-临床神经学

CiteScore

5.60

自引率

7.10%

发文量

191

审稿时长

6-12 weeks

期刊介绍： The goal of Neurosurgical Review is to provide a forum for comprehensive reviews on current issues in neurosurgery. Each issue contains up to three reviews, reflecting all important aspects of one topic (a disease or a surgical approach). Comments by a panel of experts within the same issue complete the topic. By providing comprehensive coverage of one topic per issue, Neurosurgical Review combines the topicality of professional journals with the indepth treatment of a monograph. Original papers of high quality are also welcome.