Antioxidant Properties of Biosurfactants: Multifunctional Biomolecules with Added Value in Formulation Chemistry.

Abstract

Biosurfactants, amphiphilic metabolites produced by bacteria and yeasts, fulfill a variety of functions in microbial life. They exhibit a well-recognized multifunctionality, spanning from the reduction in surface tension to specific biological activities, including antimicrobial, antiviral, anti-inflammatory, and anticancer effects. These compounds have the potential to serve as environmentally friendly alternatives to synthetic surfactants in industrial formulations, where they could act as emulsifiers and wetting agents. The exploitation of their full potentiality could be a significant added value. Biosurfactants are often cited as effective antioxidants. However, experimental evidence for their antioxidant activity/capacity is sparse. To shed light on the subject, in this review we collect and critically examine all the available literature data for each of the major classes of microbial biosurfactants: rhamnolipids, mannosylerythritol lipids, sophorolipids, and lipopeptides. Despite the variability arising from the diverse composition and polydispersity of the samples analyzed, along with the variety of testing methodologies, the findings consistently indicate a moderate-to-strong antioxidant capacity. Several hypotheses are advanced about the molecular mechanisms behind this action; however, further studies are needed to gain a molecular understanding. This knowledge would fully define the biological roles of biosurfactants and is a prerequisite for the development of innovative formulations based on the valorization of their antioxidant properties.