Assessment of Piezo1 Expression in Urinary Exfoliated Cells as a Diagnostic Indicator for Multiple System Atrophy

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2025-02-26 DOI:10.1002/mds.30132

Han Liu MD, Qingyong Zhu MD, Jiuqi Wang MM, Chi Qin MM, Renyi Feng MM, Heng Wu MD, Beisha Tang MD, Junfang Teng MM, Mingming Ma MD, Xuebing Ding MD, Xuejing Wang MD

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引用次数: 0

Abstract

Background

Multiple system atrophy (MSA) shares clinical features with idiopathic Parkinson’ s disease (iPD) and progressive supranuclear palsy (PSP), yet reliable biomarkers for differential diagnosis remain elusive.

Objectives

This study aimed to evaluate Piezo1/2 expression in urinary exfoliated cells as a potential biomarker for MSA differentiation.

Methods

Piezo1/2 expression levels were quantified in urinary exfoliated cells from 76 MSA patients, 103 iPD patients, 59 PSP patients, and 126 healthy controls (HCs) across three independent cohorts using multiple analytical techniques.

Results

In the discovery cohort, Piezo1 expression was significantly reduced in MSA patients compared with HCs, iPD, and PSP (area under the curve: 0.9421, 0.8218, and 0.8036, respectively). These findings were validated in two independent cohorts, confirming consistently lower Piezo1 levels in MSA patients and their utility in distinguishing MSA from other groups.

Conclusion

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尿脱落细胞中Piezo1表达作为多系统萎缩诊断指标的评估。

背景：多系统萎缩（MSA）与特发性帕金森病（iPD）和进行性核上性麻痹（PSP）具有相同的临床特征，但鉴别诊断的可靠生物标志物仍然难以捉摸。目的：本研究旨在评估尿脱落细胞中Piezo1/2的表达作为MSA分化的潜在生物标志物。方法：采用多种分析技术，对76例MSA患者、103例iPD患者、59例PSP患者和126例健康对照（hc）的尿脱落细胞中的Piezo1/2表达水平进行量化。结果：在发现队列中，与hcc、iPD和PSP患者相比，MSA患者的Piezo1表达明显降低（曲线下面积分别为0.9421、0.8218和0.8036）。这些发现在两个独立的队列中得到了验证，证实了MSA患者的Piezo1水平始终较低，并且可以将MSA与其他组区分开来。结论：尿脱落细胞中Piezo1水平的降低作为诊断MSA的非侵入性生物标志物具有很强的潜力。©2025国际帕金森和运动障碍学会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.