Initiation and Discontinuation of Psychotropic Drugs Relative to Suicidal Behavior: A Danish Registry-Based Study.

IF 5.3 2区 医学 Q1 PSYCHIATRY
Mette Reilev, Jacob Harbo Andersen, Mikkel Højlund, Elsebeth Stenager, Lotte Rasmussen, Erik Christiansen
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引用次数: 0

Abstract

Introduction: Changes in psychotropic drug use relative to suicidal behavior could potentially inform the timing of preventive efforts. We aimed to describe the initiation and discontinuation of psychotropic drugs relative to suicide and suicide attempts.

Methods: The Danish registries were used to describe incidents and prevalent use of psychotropic drugs 2 years before and after a suicide attempt and before suicide. Discontinuation of psychotropic drugs in the 6-month period prior to suicide and suicide attempts was estimated. Analyses were stratified by drug groups, sex, and age.

Results: Among 5.8 million Danish citizens(2021), 6374 died by suicide, and 29,332 had a first-ever suicide attempt from 2010 to 2021. Use of psychotropic drugs increased markedly in the 6 months prior to suicide and suicide attempt, e.g., up to 18 incident drug redemptions and 92 prevalent drug redemptions per 100 persons in the month before suicide. The highest rates of both incident and prevalent drug redemptions were observed immediately after the suicide attempt. Psychotropic drug use was generally lower among men. Immediately after the suicide attempt, however, men exhibited a slightly higher level of incident use than women. Ten percent discontinued psychotropic drugs completely in the 6-month period before suicide, while 48% discontinued drugs used in alcohol abuse.

Conclusion: We found a marked increase in psychotropic drug use before suicide and before and after attempted suicide. Complete pre-attempt discontinuation of psychotropic drugs was low, though approximately half discontinued drugs used for alcohol abuse. The process of prescribing psychotropic drugs may represent an opportunity for prevention.

服用和停用精神药物与自杀行为相关:丹麦一项基于登记的研究。
导言:与自杀行为相关的精神药物使用的变化可以潜在地告知预防措施的时机。我们的目的是描述与自杀和自杀企图有关的精神药物的开始和停止。方法:采用丹麦的登记资料,描述自杀未遂前后和自杀前2年精神药物的事件和流行情况。估计在自杀和企图自杀前6个月内精神药物的停药情况。分析按药物组、性别和年龄进行分层。结果:在580万丹麦公民(2021年)中,6374人死于自杀,29332人在2010年至2021年期间首次自杀未遂。在自杀或企图自杀前的6个月内,精神药物的使用明显增加,例如,在自杀前的一个月内,每100人有多达18次意外药物赎回和92次普遍药物赎回。在自杀未遂后立即观察到最高的事件和普遍药物赎回率。精神药物的使用在男性中普遍较低。然而,在自杀未遂后,男性的意外使用水平略高于女性。10%的人在自杀前的6个月内完全停止使用精神药物,而48%的人停止使用用于酗酒的药物。结论:自杀前、自杀未遂前后精神药物使用明显增加。企图前完全停止使用精神药物的情况很少,但大约有一半停止使用用于酗酒的药物。开精神药物处方的过程可能是预防的机会。
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来源期刊
Acta Psychiatrica Scandinavica
Acta Psychiatrica Scandinavica 医学-精神病学
CiteScore
11.20
自引率
3.00%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.
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