People with four-class drug-resistant HIV-1 may have low levels of intact DNA.

IF 3.4 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2025-03-15 Epub Date: 2025-02-27 DOI:10.1097/QAD.0000000000004066

Camilla Muccini, Vincenzo Spagnuolo, Maurizio Zazzi, Antonella Castagna, Daniela Cesana

引用次数: 0

Abstract

We evaluated the HIV-1 reservoir in people with four-class drug-resistant (4DR) virus compared with those without drug resistance. Using the intact proviral DNA assay, we found that both groups had similar levels of intact HIV-1 DNA, suggesting that multidrug-resistant HIV does not significantly alter the size of the reservoir. These findings are a first step in studying the HIV-1 reservoir in the population with multidrug-resistant virus, and further studies are needed to confirm our results.

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四类耐药 HIV-1 感染者的完整 DNA 含量可能较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

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