Development of a Thoracoscopic Model for Birth Defect Esophageal Atresia and Tracheoesophageal Fistula Using Fresh Sheep Tissues

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2025-02-27 DOI:10.1002/bdr2.2458

Mustafa Azizoglu, Mehmet Hanifi Okur

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引用次数: 0

Abstract

Background

This study aimed to develop an esophageal atresia (EA) model using fresh sheep esophagus, trachea, and lungs to simulate a realistic thoracoscopic surgical environment.

Methods

A thoracoscopic trainer box was used with fresh sheep tissues (esophagus, trachea, and lungs) to create an EA and tracheoesophageal fistula (TEF) model. The distal esophagus was anastomosed to the trachea, and a bicycle pump was integrated to simulate lung function. Additional components, such as a simulated azygos vein and parietal pleura, enhanced the model's realism for surgical training.

Results

The developed EA-TEF model was created in six steps, including pleural dissection, azygos vein control, TEF division, and esophageal anastomosis. The procedure used a thoracoscopic trainer box, sheep tissues, and standard instruments. A bicycle pump simulated lung function, and careful techniques were employed for vein ligation and esophageal anastomosis. After the posterior wall was sutured, an 8 Fr feeding tube was inserted. The total cost of the model was $260, with reusable equipment and a $10 recurring cost for sheep tissues.

Conclusions

This study successfully developed a cost-effective and anatomically accurate thoracoscopic model for EA and TEF repair using fresh sheep tissue.

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绵羊新鲜组织胸腔镜下先天性食管闭锁及气管食管瘘模型的建立

本研究旨在建立一个食管闭锁（EA）模型，利用新鲜绵羊的食管、气管和肺来模拟真实的胸腔镜手术环境。方法采用胸腔镜训练箱和新鲜羊组织（食管、气管和肺）制作EA和气管食管瘘（TEF）模型。远端食道与气管吻合，并集成了一个自行车打气筒来模拟肺功能。额外的组件，如模拟奇静脉和胸膜壁层，增强了模型的现实主义的手术训练。结果建立的EA-TEF模型分为胸膜剥离、奇静脉控制、TEF分割、食管吻合6个步骤。该手术使用了胸腔镜训练箱、羊组织和标准器械。自行车打气筒模拟肺功能，并采用谨慎的技术进行静脉结扎和食管吻合。后壁缝合后，插入8fr饲管。该模型的总成本为260美元，包括可重复使用的设备和10美元的羊组织循环成本。结论本研究成功地建立了一种成本效益高、解剖准确的胸腔镜模型，用于用新鲜羊组织修复EA和TEF。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.