Hypertriglyceridemia-modulated gut microbiota promotes lysophosphatidylcholine generation to aggravate acute pancreatitis in a TLR4-dependent manner

IF 23.7 Q1 MICROBIOLOGY
iMeta Pub Date : 2025-02-11 DOI:10.1002/imt2.70003
Xiaofan Song, Lei Qiao, Xina Dou, Jiajing Chang, Xiaonan Zeng, Tianjing Deng, Ge Yang, Peiyun Liu, Cheng Wang, Qinhong Xu, Chunlan Xu
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引用次数: 0

Abstract

Hypertriglyceridemia (HTG) can lead to the disorder of gut microbiota in mice, resulting in the increase of endotoxin content. HTG can also aggravate the damage of intestinal barrier function and intestinal bacterial translocation in acute pancreatitis (AP) mice. Toll-like receptor 4 gene (Tlr4) knockout can significantly reduce gut permeability and endotoxin invasion in AP mice. In addition, HTG-modulated gut microbiota could up-regulate glycerophospholipid metabolism and increase lysophosphatidylcholine (LysoPC) content in a TLR4-dependent manner, thereby aggravating pancreatic injury in AP.

Abstract Image

高甘油三酯血症调节的肠道微生物群以tlr4依赖的方式促进溶血磷脂酰胆碱的产生,加重急性胰腺炎
高甘油三酯血症(HTG)可导致小鼠肠道菌群紊乱,导致内毒素含量增加。HTG还可加重急性胰腺炎(AP)小鼠肠道屏障功能损伤和肠道细菌易位。敲除toll样受体4基因(Tlr4)可显著降低AP小鼠肠道通透性和内毒素侵袭。此外,htg调节的肠道微生物群以tlr4依赖的方式上调甘油磷脂代谢,增加溶血磷脂酰胆碱(LysoPC)含量,从而加重AP的胰腺损伤。
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