Non-differential gut microbes contribute to hypertension and its severity through co-abundances: A multi-regional prospective cohort study

IF 23.7 Q1 MICROBIOLOGY
iMeta Pub Date : 2025-01-10 DOI:10.1002/imt2.268
Lu Liu, Qianyi Zhou, Tianbao Xu, Qiufeng Deng, Yuhao Sun, Jingxiang Fu, Muxuan Chen, Xiaojiao Chen, Zhenchao Ma, Quanbin Dong, Beining Ma, Yuwen Jiao, Yan Zhou, Tingting Wu, Huayiyang Zou, Jing Shi, Yifeng Wang, Yanhui Sheng, Liming Tang, Chao Zheng, Wei Wu, Wenjun Ma, Wei Sun, Shixian Hu, Hongwei Zhou, Yan He, Xiangqing Kong, Lianmin Chen
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引用次数: 0

Abstract

Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research has primarily focused on differential abundances, our study highlights the role of non-differential microbes in hypertension. We propose that non-differential microbes contribute to hypertension through their ecological interactions, as defined by co-abundances (pairs of microbes exhibiting correlated abundance patterns). Using gut microbiome data from the Guangdong Gut Microbiome Project, which includes 2355 hypertensive and 4644 non-hypertensive participants across 14 regions, we identified replicable hypertension-related microbial interactions. Notably, most co-abundances involved non-differential microbes, which were found to correlate with both hypertension severity and hypertension-related microbial metabolic pathways. These findings emphasize the importance of microbial interactions in hypertension pathogenesis and propose a novel perspective for microbiome-based therapeutic strategies.

Abstract Image

非差异性肠道微生物通过共丰度参与高血压及其严重程度:一项多地区前瞻性队列研究
以微生物群落结构和功能不平衡为特征的微生物生态失调与高血压有关。虽然之前的研究主要集中在差异丰度上,但我们的研究强调了非差异微生物在高血压中的作用。我们提出,非差异微生物通过它们的生态相互作用来促进高血压,正如共同丰度(表现出相关丰度模式的微生物对)所定义的那样。利用广东肠道微生物组项目的肠道微生物组数据,包括14个地区的2355名高血压患者和4644名非高血压患者,我们确定了可复制的高血压相关微生物相互作用。值得注意的是,大多数共丰度涉及非差异微生物,这些微生物被发现与高血压严重程度和高血压相关的微生物代谢途径相关。这些发现强调了微生物相互作用在高血压发病机制中的重要性,并为基于微生物组的治疗策略提出了新的视角。
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CiteScore
10.80
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