Understanding the Burden and Management of Urinary Tract Infections in Women.

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Baiken Baimakhanova, Amankeldi Sadanov, Lyudmila Trenozhnikova, Assya Balgimbaeva, Gul Baimakhanova, Saltanat Orasymbet, Diana Tleubekova, Alma Amangeldi, Zere Turlybaeva, Zhanar Nurgaliyeva, Roza Seisebayeva, Zhanat Kozhekenova, Saltanat Sairankyzy, Zhanserik Shynykul, Sandugash Yerkenova, Aknur Turgumbayeva
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Abstract

Urinary tract infections (UTIs) represent a prevalent health concern among the female population, with anatomical and physiological determinants such as a shorter urethra and its proximity to the rectum augmenting vulnerability. The presence of Escherichia coli and various other pathogens plays a significant role in the etiology of these infections, which can be aggravated by sexual intercourse and disturbances to the vaginal microbiome. The physiological alterations associated with pregnancy further elevate the likelihood of UTIs, with untreated cases potentially leading to severe complications such as pyelonephritis, preterm labor, and stillbirth. Furthermore, postmenopausal women encounter an augmented risk of UTIs attributable to estrogen deficiency and vaginal atrophy, as well as conditions including pelvic organ prolapse (POP) and urinary incontinence (UI), which hinder optimal bladder functionality. The aforementioned factors, in conjunction with the rising prevalence of cesarean deliveries and catheterization, complicate the management of UTIs. While precise diagnosis is paramount, it remains a formidable challenge, notwithstanding advancements in molecular diagnostic techniques. Management strategies encompass antibiotic-sparing therapies; however, the increasing incidence of multidrug resistance represents an alarming trend. Diverse guidelines from various medical specialties endeavor to standardize treatment approaches, yet significant inconsistencies continue to exist. This study systematically appraises the extant guidelines, evaluating the quality of evidence while identifying areas of agreement and discord to supply practitioners with effective strategies for UTI management.

了解女性尿路感染的负担和管理。
尿路感染(uti)是女性人群中普遍存在的健康问题,其解剖学和生理学决定因素,如尿道较短及其靠近直肠,增加了易感性。大肠杆菌和各种其他病原体的存在在这些感染的病因学中起着重要作用,这些感染可因性交和阴道微生物群的紊乱而加重。与妊娠相关的生理改变进一步增加了尿路感染的可能性,未经治疗的病例可能导致严重的并发症,如肾盂肾炎、早产和死胎。此外,绝经后妇女由于雌激素缺乏和阴道萎缩,以及盆腔器官脱垂(POP)和尿失禁(UI)等阻碍膀胱最佳功能的疾病,会增加尿路感染的风险。上述因素,加上剖宫产和导尿术的日益流行,使尿路感染的管理复杂化。虽然精确诊断是最重要的,但尽管分子诊断技术取得了进步,它仍然是一个艰巨的挑战。管理策略包括节省抗生素治疗;然而,多药耐药发生率的增加是一个令人震惊的趋势。来自不同医学专业的不同指南努力使治疗方法标准化,但显著的不一致仍然存在。本研究系统地评估现有的指导方针,评估证据的质量,同时确定一致和不一致的领域,为从业者提供有效的尿路感染管理策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.80
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0.00%
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审稿时长
6 weeks
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