A possible role for epigenetics in cancer initiation.

IF 0.7 4区 生物学 Q4 BIOLOGY
Anne-Marie Martinez, Giacomo Cavalli
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引用次数: 0

Abstract

Cancer is one of the leading causes of mortality worldwide. Known since antiquity, its understanding has evolved over time and has significantly advanced with new technologies over the past four decades. Cancer initiation is currently admitted to be explainable by the somatic mutation theory, which postulates that DNA mutations altering the function of oncogenes and tumor suppressor genes initiate cancer. In addition to these mutations, epigenetic alterations, which heritably change gene expression without altering the DNA sequence, also play a key role. Recent data suggests that epigenetic components regulate all aspects of tumor progression, including cancer initiation. These discoveries prompt a reevaluation of the somatic mutation theory, of cancer prevention and treatment strategies.

表观遗传学在癌症发生中的可能作用。
癌症是全球死亡的主要原因之一。自古以来就为人所知,它的理解随着时间的推移而发展,在过去的四十年里,随着新技术的发展,它取得了显著的进步。癌症的发生目前被认为可以用体细胞突变理论来解释,该理论假设DNA突变改变了癌基因和肿瘤抑制基因的功能,从而引发了癌症。除了这些突变之外,表观遗传改变,即在不改变DNA序列的情况下遗传性地改变基因表达,也起着关键作用。最近的数据表明,表观遗传成分调节肿瘤进展的各个方面,包括癌症的发生。这些发现促使对体细胞突变理论、癌症预防和治疗策略的重新评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Comptes Rendus Biologies
Comptes Rendus Biologies 生物-生物学
CiteScore
2.40
自引率
0.00%
发文量
22
审稿时长
3 months
期刊介绍: The Comptes rendus Biologies publish monthly communications dealing with all biological and medical research fields (biological modelling, development and reproduction biology, cell biology, biochemistry, neurosciences, immunology, pharmacology, ecology, etc.). Articles are preferably written in English. Articles in French with an abstract in English are accepted.
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