Occurrence of Metabolic Disorders in Bilateral Primary Aldosteronism Compared to Unilateral Primary Aldosteronism.

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Chiara Grasselli, Maicol Baldini, Lucia Salvi, Grazia Vestita, Maurizio Zizzo, Davide Felaco, Maria Carolina Balli, Giulia Besutti, Aurelio Negro, Angelo Ghirarduzzi
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Abstract

Background: Metabolic syndrome (MetS) is a common comorbidity associated with hypertension that occurs more often in primary aldosteronism (PA). Our work aims to investigate the prevalence of MetS and its determinants in unilateral PA and bilateral PA, as confirmed by adrenal venous sampling (AVS).

Methods: This was a retrospective, cross-sectional study. We investigated metabolic indicators in 160 cases of PA, categorized by AVS-82 with unilateral PA and 78 with bilateral PA. A control group of 80 non-PA patients with essential hypertension, matched for age and sex, was also included.

Results: Unilateral PA had a higher aldosterone-renin ratio and lower serum potassium levels than bilateral PA. Nevertheless, bilateral PA exhibited a higher prevalence of MetS (41% vs. 30.5%; p = 0.001), obesity, BMI, LDL hypercholesterolemia, and hypertriglyceridemia than unilateral PA.

Conclusions: Bilateral PA presents a greater incidence of MetS than unilateral PA, in spite of the latter showing a higher aldosterone-renin ratio and lower serum potassium levels. The results suggest that the mechanisms underlying MetS may differ between unilateral and bilateral PA.

双侧原发性醛固酮增多症与单侧原发性醛固酮增多症代谢性疾病的比较。
背景:代谢综合征(MetS)是一种与高血压相关的常见合并症,常见于原发性醛固酮增多症(PA)。我们的工作旨在通过肾上腺静脉采样(AVS)证实,调查met在单侧和双侧PA中的患病率及其决定因素。方法:回顾性横断面研究。我们对160例PA的代谢指标进行了研究,其中单侧PA的AVS-82和双侧PA的78例进行了分类。对照组包括80名年龄和性别相匹配的非pa型高血压患者。结果:单侧PA的醛固酮-肾素比值高于双侧PA,血清钾水平低于双侧PA。然而,双侧PA表现出更高的MetS患病率(41% vs. 30.5%;p = 0.001)、肥胖、BMI、LDL高胆固醇血症和高甘油三酯血症的发生率高于单侧PA。结论:尽管单侧PA具有较高的醛固酮-肾素比值和较低的血清钾水平,但双侧PA的met发生率高于单侧PA。结果表明,MetS的机制可能在单侧和双侧PA之间有所不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
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