An increase in the urinary levels of prostaglandin D₂ and platelet-activating factor metabolites in dogs with mast cell tumor.

IF 1.1 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Veterinary Medical Science Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI:10.1292/jvms.24-0525

Arisa Yamazaki, Akane Hayashi, Tatsuro Nakamura, Yuta Hamasaki, Rikako Inoue, Sho Yoshimoto, Koji Kobayashi, Takayuki Nakagawa, Takahisa Murata

引用次数: 0

Abstract

The diagnosis of canine mast cell tumor (MCT) via cytology carries the risk of triggering life-threatening anaphylactic reactions due to massive histamine release. Since mast cells release various lipid mediators, which are excreted in urine, we aimed to explore urinary lipid metabolites as potential non-invasive diagnostic markers for MCT. Liquid chromatography-mass spectrometry-based analysis detected 32 types of lipid metabolites in the urine of MCT dogs. Among these, urinary levels of 15-deoxy-Δ-12,14-PGJ₂, lyso-PAF, 9,10-DiHOME, and 12,13-DiHOME were significantly elevated in MCT dogs compared to healthy dogs. These urinary lipid metabolites can serve as novel non-invasive biomarkers for canine MCT.

查看原文本刊更多论文

肥大细胞瘤犬尿中前列腺素D2和血小板活化因子代谢物水平的升高。

犬肥大细胞瘤（MCT）的细胞学诊断有引发危及生命的过敏反应的风险，因为大量的组胺释放。由于肥大细胞释放各种脂质介质，这些介质通过尿液排出，我们旨在探索尿脂代谢产物作为MCT潜在的非侵入性诊断标志物。基于液相色谱-质谱的分析在MCT犬尿液中检测到32种脂质代谢物。其中，与健康犬相比，MCT犬尿液中的15-脱氧-δ-12,14- pgj2、lyso-PAF、9,10- dihome和12,13- dihome水平显著升高。这些尿脂代谢产物可作为犬MCT的新型无创生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Veterinary Medical Science 农林科学-兽医学

CiteScore

2.30

自引率

8.30%

发文量

230

审稿时长

9-18 weeks

期刊介绍： JVMS is a peer-reviewed journal and publishes a variety of papers on veterinary science from basic research to applied science and clinical research. JVMS is published monthly and consists of twelve issues per year. Papers are from the areas of anatomy, physiology, pharmacology, toxicology, pathology, immunology, microbiology, virology, parasitology, internal medicine, surgery, clinical pathology, theriogenology, avian disease, public health, ethology, and laboratory animal science. Although JVMS has played a role in publishing the scientific achievements of Japanese researchers and clinicians for many years, it now also accepts papers submitted from all over the world.

An increase in the urinary levels of prostaglandin D2 and platelet-activating factor metabolites in dogs with mast cell tumor.

Abstract

An increase in the urinary levels of prostaglandin D₂ and platelet-activating factor metabolites in dogs with mast cell tumor.