Can exclusive breastfeeding in the first 4 months reduce food allergy?

IF 5.8 2区医学 Q1 ALLERGY

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-01 DOI:10.1016/j.anai.2025.02.011

Nadira Musallam MD, Meital Almog MD, Roni Wagner RD, Larisa Epov MD, Vika Dor MD, Aharon Kessel MD

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引用次数: 0

Abstract

Background

IgE-mediated food allergy (FA) is a major global health concern. Although the early introduction of allergenic foods and breastfeeding are potential preventive strategies, the role of breast milk in reducing the incidence of FAs remains inconclusive.

Objective

To investigate the impact of exclusive breastfeeding for the first 4 months compared with partial breastfeeding or cow's milk formula (CMF) on the development of IgE-mediated FAs in an Israeli cohort.

Methods

A cross-sectional online survey in 3030 mothers with infants aged 6 to 24 months collected data on early feeding practices, allergen introduction, atopic conditions, and family history. It documented suspected allergic reactions, symptoms, and diagnostic procedures.

Results

Of the 3030 mothers surveyed, 2920 provided complete feeding data for the first 4 months. Among them, 39.0% exclusively breastfed, 12.1% used CMF, and 48.9% partially breastfed. There were 392 infants with FAs, totaling 480 cases involving cow's milk, sesame, egg, or peanut. Of these cases, 122 (25.4%) were in the breastfeeding group, and 358 (74.6%) were in the other groups. Exclusively breastfed infants had lower odds of egg (odds ratio [OR] = 0.53), sesame (OR = 0.58), and peanut (OR = 0.53) allergies than others. The interaction between feeding patterns and atopic dermatitis (AD) related to these FAs was not significant. Exposure to CMF in the nursery, exclusively breastfed, was associated with higher odds of developing a cow's milk allergy. Delayed exposure to sesame in infants with AD has been linked to increased odds of developing a sesame allergy.

Conclusion

Exclusive breastfeeding may reduce the risk of IgE-mediated FA development, regardless of AD status.

查看原文本刊更多论文

头 4 个月纯母乳喂养能否减少食物过敏？一项回顾性问卷调查研究。

背景：IgE 介导的食物过敏是全球关注的主要健康问题。虽然早期引入致敏食物和母乳喂养是潜在的预防策略，但母乳在降低食物过敏发病率方面的作用仍无定论：我们的目的是在以色列队列中调查头四个月纯母乳喂养与部分母乳喂养或牛奶粉（CMF）相比对 IgE 介导的食物过敏（FAs）发生的影响：对 3,030 名有 6-24 个月婴儿的母亲进行了横断面在线调查，收集了有关早期喂养方式、过敏原引入、特应性疾病和家族史的数据。调查还记录了疑似过敏反应、症状和诊断过程：在接受调查的 3030 位母亲中，有 2920 位提供了头 4 个月的完整喂养数据。其中，39.0%为纯母乳喂养，12.1%使用CMF，48.9%为部分母乳喂养。有392名婴儿患有FA，其中480例涉及牛奶、芝麻、鸡蛋或花生。其中，母乳喂养组有 122 例（25.4%），其他组有 358 例（74.6%）。与其他婴儿相比，纯母乳喂养的婴儿发生鸡蛋（OR=0.53）、芝麻（OR=0.58）和花生（OR=0.53）过敏的几率较低。喂养模式与特应性皮炎（AD）之间与这些脂肪酸相关的交互作用不显著。在育婴室接触 CMF 和纯母乳喂养与较高的牛乳过敏发病几率有关。患有 AD 的婴儿延迟接触芝麻与芝麻过敏几率增加有关：结论：纯母乳喂养可降低 IgE 介导的 FA 的发病几率，与 AD 状况无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Allergy Asthma & Immunology 医学-过敏

CiteScore

6.50

自引率

6.80%

发文量

437

审稿时长

33 days

期刊介绍： Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.