Signal Differentiation of Moving Magnetic Nanoparticles for Enhanced Biodetection and Diagnostics.

IF 4.9 3区工程技术 Q1 CHEMISTRY, ANALYTICAL

Biosensors-Basel Pub Date : 2025-02-17 DOI:10.3390/bios15020116

Kee Young Hwang, Dakota Brown, Supun B Attanayake, Dan Luu, Minh Dang Nguyen, T Randall Lee, Manh-Huong Phan

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引用次数: 0

Abstract

Magnetic nanoparticles are extensively utilized as markers/signal labelling in various biomedical applications. Detecting and distinguishing magnetic signals from similarly sized moving magnetic nanoparticles in microfluidic systems is crucial yet challenging for biosensing. In this study, we have developed an original method to detect and differentiate magnetic signals from moving superparamagnetic (SPM) and ferrimagnetic (FM) nanoparticles of comparable sizes. Our approach utilizes a highly sensitive magnetic-coil-based sensor that harnesses the combined effects of giant magnetoimpedance (GMI) and an LC-resonance circuit, offering performance superior to that of conventional GMI sensors. Iron oxide nanoparticles, which have similar particle sizes but differing coercivities (zero for SPM and non-zero for FM) or similar zero coercivities but differing particle sizes, flow through the magnetic coil at controlled velocities. Their distinct effects are analyzed through changes in the complex impedance of the sensing system. Our findings provide a unique pathway for utilizing SPM and FM nanoparticles as innovative magnetic markers to identify specific biological entities, thereby expanding their potential applications.

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移动磁性纳米粒子的信号分辨，用于增强生物检测和诊断。

磁性纳米颗粒在各种生物医学应用中广泛用作标记物/信号标记。在微流体系统中，从大小相似的移动磁性纳米颗粒中检测和区分磁信号是生物传感的关键，但也是具有挑战性的。在这项研究中，我们开发了一种原始的方法来检测和区分大小相当的移动超顺磁（SPM）和亚铁磁（FM）纳米颗粒的磁信号。我们的方法利用高灵敏度的基于磁线圈的传感器，利用巨磁阻抗（GMI）和lc谐振电路的综合效应，提供优于传统GMI传感器的性能。氧化铁纳米颗粒具有相似的粒径但不同的矫顽力（SPM为零，FM为非零）或相似的零矫顽力但不同的粒径，以受控的速度流过磁线圈。通过传感系统复杂阻抗的变化分析了它们的不同影响。我们的发现为利用SPM和FM纳米颗粒作为创新的磁性标记物来识别特定的生物实体提供了一条独特的途径，从而扩大了它们的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biosensors-Basel Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

6.60

自引率

14.80%

发文量

983

审稿时长

11 weeks

期刊介绍： Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.