The Latest Advances in Microfluidic DLD Cell Sorting Technology: The Optimization of Channel Design.

IF 4.9 3区工程技术 Q1 CHEMISTRY, ANALYTICAL

Biosensors-Basel Pub Date : 2025-02-19 DOI:10.3390/bios15020126

Dan Fan, Yi Liu, Yaling Liu

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Abstract

Cell sorting plays a crucial role in both medical and biological research. As a key passive sorting technique in the field of microfluidics, deterministic lateral displacement (DLD) has been widely applied to cell separation and sorting. This review aims to summarize the latest advances in the optimization of channel design for microfluidic DLD cell sorting. First, we provide an overview of the design elements of microfluidic DLD cell sorting channels, focusing on key factors that affect separation efficiency and accuracy, including channel geometry, fluid dynamics, and the interaction between cells and channel surfaces. Subsequently, we review recent innovations and progress in channel design for microfluidic DLD technology, exploring its applications in biomedical fields and its integration with machine learning. Additionally, we discuss the challenges currently faced in optimizing channel design for microfluidic DLD cell sorting. Finally, based on existing research, we make a summary and put forward prospective views on the further development of this field.

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微流体DLD细胞分选技术的最新进展：通道设计的优化。

细胞分选在医学和生物学研究中都起着至关重要的作用。作为微流体领域一项关键的被动分选技术，确定性横向位移（DLD）技术在细胞分离和分选中得到了广泛的应用。本文综述了微流控DLD细胞分选通道优化设计的最新进展。首先，我们概述了微流体DLD细胞分选通道的设计要素，重点介绍了影响分离效率和精度的关键因素，包括通道几何形状、流体动力学以及细胞与通道表面之间的相互作用。随后，我们回顾了微流控DLD技术在通道设计方面的最新创新和进展，探讨了其在生物医学领域的应用及其与机器学习的结合。此外，我们还讨论了目前在优化微流体DLD细胞分选通道设计方面面临的挑战。最后，在现有研究的基础上，对该领域的进一步发展进行了总结和展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biosensors-Basel Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

6.60

自引率

14.80%

发文量

983

审稿时长

11 weeks

期刊介绍： Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.