Interleukin-6 and Procalcitonin as Potential Predictors of Acute Kidney Injury Occurrence in Patients with Sepsis.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Reports of Biochemistry and Molecular Biology Pub Date : 2024-07-01 DOI:10.61186/rbmb.13.2.144

Liliriawati Ananta Kahar

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引用次数: 0

Abstract

Background: Timely treatment actions are critical for the early detection of sepsis in patients at high risk of acute kidney injury (AKI). This study aimed to investigate inflammatory biomarkers as potential predictors of AKI in patients with sepsis.

Methods: This prospective observational cohort study included 300 patients who received treatment in the Intensive Care Unit (ICU) of hospitals located in Padang, Indonesia. We obtained blood samples to evaluate inflammatory biomarkers, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and procalcitonin (PCT). AKI development was predicted using multivariate logistic regression analysis to identify independent inflammatory biomarkers.

Results: IL-6, TNF-α, and PCT levels were markedly elevated in patients who developed AKI compared with those who did not (p < 0.001). The multivariable logistic regression analysis showed that IL-6 (OR = 1.82; 95% CI = 1.25-2.66; p = 0.002) and PCT (OR = 2.45; 95% CI = 1.58-3.80; p < 0.001) can both predict the development of AKI in patients with sepsis. The area under the curve (AUC) for IL-6 was 0.70, whereas the AUC for PCT was 0.81. These findings demonstrate that IL-6 and PCT exhibit strong predictive abilities for the onset of AKI in patients with sepsis. The ideal threshold values for IL-6 and PCT were 12.91 pg/mL and 1.79 ng/mL, respectively.

Conclusions: IL-6 and PCT can serve as inflammatory biomarkers for predicting the occurrence of AKI in patients with sepsis.

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白细胞介素-6和降钙素原作为脓毒症患者急性肾损伤发生的潜在预测因子。

背景：及时的治疗行动对于早期发现高风险急性肾损伤（AKI）患者脓毒症至关重要。本研究旨在探讨炎症生物标志物作为脓毒症患者AKI的潜在预测因素。方法：这项前瞻性观察队列研究纳入了300名在印度尼西亚巴东医院重症监护病房（ICU）接受治疗的患者。我们获得血液样本来评估炎症生物标志物，如白细胞介素-6 （IL-6）、肿瘤坏死因子-α (TNF-α)和降钙素原（PCT）。使用多变量logistic回归分析来预测AKI的发展，以确定独立的炎症生物标志物。结果：与未发生AKI的患者相比，发生AKI的患者IL-6、TNF-α和PCT水平明显升高（p < 0.001）。多变量logistic回归分析显示，IL-6 (OR = 1.82；95% ci = 1.25-2.66；p = 0.002)和PCT (OR = 2.45；95% ci = 1.58-3.80；p < 0.001)均能预测脓毒症患者AKI的发展。IL-6的曲线下面积（AUC）为0.70，PCT的AUC为0.81。这些发现表明，IL-6和PCT对脓毒症患者AKI的发生具有很强的预测能力。IL-6和PCT的理想阈值分别为12.91 pg/mL和1.79 ng/mL。结论：IL-6和PCT可作为预测脓毒症患者AKI发生的炎症生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

10 weeks

期刊介绍： The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.